info:eu-repo/semantics/article
Modified ribavirin analogues as antiviral agents against Junín virus
Fecha
2019-02Registro en:
Contin, Mario Daniel; Sepúlveda, Claudia Soledad; Fascio, Mirta Liliana; Stortz, Carlos Arturo; Damonte, Elsa Beatriz; et al.; Modified ribavirin analogues as antiviral agents against Junín virus; Elsevier; Biorganic and Medicinal Chemistry Letters; 29; 4; 2-2019; 556-559
0960-894X
CONICET Digital
CONICET
Autor
Contin, Mario Daniel
Sepúlveda, Claudia Soledad
Fascio, Mirta Liliana
Stortz, Carlos Arturo
Damonte, Elsa Beatriz
D'accorso, Norma Beatriz
Resumen
In this work, several ribavirin analogues were synthesized and incorporated into a multivalent arrangement. Both were subsequently modified by the addition of polyhydroxylated residues. Their antiviral activity was tested against Junín virus, etiological agent responsible of Argentine hemorrhagic fever. Some compounds inhibited Junín virus in the range of 13.2–389.1 µM. Two modified ribavirin analogues presented an effective concentration comparable to ribavirin but with a higher selectivity index.