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Chitosan-triclosan particles modulate inflammatory signaling in gingival fibroblasts
(Wiley, 2018-04)
Background and Objectives: An important goal of periodontal therapy is the modulation of the inflammatory response. To this end, several pharmacological agents have been evaluated. Triclosan corresponds to an antibacterial ...
Effect of bakuchiol on leukocyte functions and some inflammatory responses in mice
(ROYAL PHARMACEUTICAL SOC GREAT BRITAIN, 1996-09)
The effects of bakuchiol, a meroterpenoid isolated from the leaves of Psoralea glandulosa L., on phospholipase A(2) (PLA(2)) activity from different sources, human neutrophil responses, zymosan air pouch and topical ...
Neuroinflammation in the pathogenesis of Alzheimer's disease. A rational framework for the search of novel therapeutic approaches
(Frontiers Research Foundation, 2014)
Alzheimer disease (AD) is the most common cause of dementia in people over 60 years
old. The molecular and cellular alterations that trigger this disease are still diffuse, one
of the reasons for the delay in finding an ...
Phenothiazine molecule provides the basic chemical structure for various classes of pharmacotherapeutic agents
(2006)
The chemical structure of phenothiazine provides a most valuable molecular template for the development of agents able to interact with a wide variety of biological processes. Synthetic phenothiazines (with aliphatic, ...
Efficacy of andrographolide in not active progressive multiple sclerosis: a prospective exploratory double-blind, parallel-group, randomized, placebo-controlled trial
(BMC, 2020)
Background Multiple sclerosis (MS) is a chronic immune mediated disease and the progressive phase appears to have significant neurodegenerative mechanisms. The classification of the course of progressive MS (PMS) has been ...
Ex vivo permeation of carprofen vehiculated by PLGA nanoparticles through porcine mucous membranes and ophthalmic tissues
(2020)
(1) Background: Carprofen (CP), 2-(6-chlorocarbazole) propionic acid, is used as an anti-inflammatory, analgesic and anti-pyretic agent and it belongs to the family of non-steroidal anti-inflammatory drugs (NSAIDs). CP has ...
Síndrome de restauración inmune asociado a tratamiento antirretroviral y criptococosis meníngea. Caso clínico
(SOC MEDICA SANTIAGO, 2006-10)
The objective of high activity antiretroviral therapy (HAART) inpatients with AIDS, is to obtain immune restoration. This means a reduction of the viral load and restitution of the CD4 cell count. A decreased rate of HIV ...
Biological evaluation of novel 6-arylbenzimidazo [1,2-c]quinazoline derivatives as inhibitors of LPS-induced TNF-alpha secretion
(SOC BIOLGIA CHILE, 2008)
This study describes the effect of novel 6-Arylbenzimidazo[1,2-c]quinazoline derivatives as tumor necrosis factor alpha (TNF-alpha) production inhibitors. The newly synthesized compounds were tested for their in vitro ...
Synthetic glycolipid activators of natural killer T cells as immunotherapeutic agents
(Nature Publishing Group, 2016)
Certain types of glycolipids have been found to have remarkable immunomodulatory properties as a result of their ability to activate specific T lymphocyte populations with an extremely wide range of immune effector properties. ...
Semisynthetic eugenol derivatives as antifungal agents against dermatophytes of the genus Trichophyton
(Microbiology SocietyReino Unido, 2019-07-01)
Purpose. Eugenol, the main component of clove bud essential oil (Eugenia caryophyllus), has been linked to antimicrobial, anti-inflammatory, insecticidal and immunomodulatory properties. The purpose of this study was to ...