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The topical nanodelivery of vismodegib enhances its skin penetration and performance in vitro while reducing its toxicity in vivo
(Multidisciplinary Digital Publishing Institute, 2021-01)
Vismodegib is a first-in-class inhibitor for advanced basal cell carcinoma treatment. Its daily oral doses present a high distribution volume and several side effects. We evaluated its skin penetration loaded in diverse ...
BSA-capped gold nanoclusters as potential theragnostic for skin diseases: Photoactivation, skin penetration, in vitro, and in vivo toxicity
(Elsevier Science, 2020-07)
BSA-capped gold nanoclusters are promising theragnostic systems that can be excited to render both fluorescence emission and reactive oxygen species. Although their synthesis and photoluminescence properties are already ...
Nano-formulation for topical treatment of precancerous lesions: skin penetration, in vitro, and in vivo toxicological evaluation
(Springer verlag, 2017-12)
With the aim of improving the topical delivery of the antineoplastic drug 5-fluorouracil (5FU), it was loaded into ultradeformableliposomes composed of soy phosphatidylcholine and sodium cholate (UDL-5FU). The liposome ...
Nanomaterials toxicity and teratogenicity in aquatic environment using Rhinella arenarum model
(Elsevier Ireland, 2016-10)
Nanotechnology is growing at an exponential rate and will undoubtedly have both beneficial and toxicological impact and consequences on health and environment. Amphibians are being increasingly used for toxicity screening ...
Clinical factors affecting the determination of radiotherapy-induced skin toxicity in breast cancer
(Korean Society for Radiation Oncology, 2021-12)
Purpose:Radiotherapy is essential for the treatment of breast cancer (BC). However, adverse effects may occur in healthy tissue, during treatment and even after several months. Although it is known that this clinical ...
Assessment of polyaniline nanoparticles toxicity and teratogenicity in aquatic environment using Rhinella arenarum model
(Academic Press Inc Elsevier Science, 2015-04)
With the rapid growth of nanotechnology and the applications of nanoparticles, environmental exposure to these particles is increasing. However, their impact in human and environmental health is not well studied. Anurans, ...
5-Fluorouracil-loaded ultradeformable liposomes for skin therapy
(American Institute of Physics Inc., 2018-07)
5-Fluorouracil (5FU) is an antineoplastic drug with a poor percutaneous permeation. For this reason, its efficacy for topical treatments is reduced to superficial or advanced skin lesions (that have already damaged the ...
Post-metamorphic development of skin glands in a true toad: Parotoids versus dorsal skin
(Wiley-liss, Div John Wiley & Sons Inc, 2017-05)
Chemical defenses in amphibians are a common antipredatory and antimicrobial strategy related to the presence of dermal glands that synthesize and store toxic or unpalatable substances. Glands are either distributed ...
Polyphenols of peanut (Arachis hypogaea L.) skin as bioprotectors of normal cells. Studies of cytotoxicity, cytoprotection and interaction with ROS
(Elsevier, 2020-04)
Arachis hypogaea L. (peanut) skin is a potential source of natural antioxidants, and several studies have suggested the possibility of producing functional ingredients from this by-product of food industry. This investigation ...
Liposomes can both enhance or reduce drugs penetration through the skin
(Nature Publishing Group, 2018-12)
The adequate formulation of topical vehicles to treat skin diseases is particularly complex. A desirable formulation should enhance the accumulation of the active drugs in the target tissue (the skin), while avoiding the ...