info:eu-repo/semantics/article
Polyphenols of peanut (Arachis hypogaea L.) skin as bioprotectors of normal cells. Studies of cytotoxicity, cytoprotection and interaction with ROS
Fecha
2020-04Registro en:
Rossi, Yanina Estefanía; Bohl, Luciana Paola; Vanden Braber, Noelia Luciana; Ballatore, María Belén; Escobar, Franco Matias; et al.; Polyphenols of peanut (Arachis hypogaea L.) skin as bioprotectors of normal cells. Studies of cytotoxicity, cytoprotection and interaction with ROS; Elsevier; Journal of Functional Foods; 67; 4-2020; 103862-103862
1756-4646
CONICET Digital
CONICET
Autor
Rossi, Yanina Estefanía
Bohl, Luciana Paola
Vanden Braber, Noelia Luciana
Ballatore, María Belén
Escobar, Franco Matias
Bodoira, Romina Mariana
Maestri, Damian
Porporatto, Carina
Cavaglieri, Lilia Reneé
Montenegro, Mariana Angélica
Resumen
Arachis hypogaea L. (peanut) skin is a potential source of natural antioxidants, and several studies have suggested the possibility of producing functional ingredients from this by-product of food industry. This investigation examined possible toxic effects of peanut skin polyphenolic extract (PSE) and its antioxidant properties using in vitro studies. PSE and its main component quercetin (QE) did not present any cytotoxicity on normal epithelial cells, rat ileum cells (IEC-18), monkey kidney cells (Vero) or human peripheral blood mononuclear cells (PBMCs) at concentrations with antioxidant effects. QE and PSE showed scavenging of the superoxide anion radical and cytoprotection, as well as reducing the reactive oxygen species (ROS) and superoxide dismutase (SOD) activity in IEC-18 cells against menadione-induced oxidative stress. This suggests that peanut skin phenolic extract could be a potential functional ingredient for foods.