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Treatment with the synthetic PPARG ligand pioglitazone ameliorates early ovarian alterations induced by dehydroepiandrosterone in prepubertal rats
(Polish Acad Sciences Inst Pharmacology, 2019-02)
Background: Peroxisome proliferator-activated receptor gamma (PPARG) is a nuclear factor that may act on the early development of ovarian follicles and on follicular steroidogenesis. However, the exact mechanism of PPARG ...
Ovarian localization of 11b-hydroxysteroid dehydrogenase (11bHSD): effects of ACTH stimulation and its relationship with bovine cystic ovarian disease
(Elsevier, 2013-10)
Cystic ovarian disease (COD) is an important cause of infertility in cattle, and ACTH has been involved in regulatory mechanisms related to ovarian function associated with ovulation, steroidogenesis, and luteal function. ...
Convergence of Wnt and Notch signaling controls ovarian cancer cell survival
(Wiley-liss, Div John Wiley & Sons Inc, 2019-05)
In the last 40 years ovarian cancer mortality rates have slightly declined and,consequently, it continues to be the fifth cause of cancer death in women. In thepresent study, we showed that β‐catenin signaling is involved ...
Hypogonadism in Pediatric Health: Adult Medicine Concepts Fail
(Elsevier Science London, 2019-12-01)
The classical definition of hypogonadism, used in adult medicine, as gonadal failure resulting in deficient steroid and gamete production, and its classification into hypergonadotropic and hypogonadotropic refer to primary ...
Neonatal exposure to bisphenol A or diethylstilbestrol alters the ovarian follicular dynamics in the lamb
(Pergamon-Elsevier Science Ltd, 2011-11)
We hypothesized that neonatal xenoestrogen exposure affects the ovarian follicular dynamics in lambs. Female lambs were exposed from postnatal day (PND) 1-14 to low doses of diethylstilbestrol (DES) or bisphenol A (BPA). ...
Impaired insulin signaling pathways affect ovarian steroidogenesis in cows with COD
(Elsevier Science, 2018-05)
Cystic ovarian disease (COD) represents an important cause of infertility in dairy cattle and is associated with multiple physiological disorders. Steroidogenesis, which is necessary to ensure normal ovarian functions, ...
IRE1α–XBP1 controls T cell function in ovarian cancer by regulating mitochondrial activity
(Nature Publishing Group, 2018-10)
Tumours evade immune control by creating hostile microenvironments that perturb T cell metabolism and effector function 1?4 . However, it remains unclear how intra-tumoral T cells integrate and interpret metabolic stress ...
A novel splicing mutation in the SLC9A3R1 gene in tumors from ovarian cancer patients
(Spandidos Publications, 2015-12)
The aim of the present study was to investigate novel molecular markers that could improve the diagnosis of ovarian cancer patients or be of predictive value. The sequence of the sodium‑hydrogen antiporter 3 regulator 1 ...
Comparing the role of anti-Müllerian hormone as a marker of FSH action in male and female fertility
(Taylor & Francis, 2019-03)
Introduction: Originally limited to the assessment of patients with congenital disorders of sexdevelopment, anti-Müllerian hormone (AMH) measurement has more recently been extended toseveral conditions affecting the ...
Changes in the expression of Heat Shock Proteins in ovaries from bovines with cystic ovarian disease induced by ACTH
(Elsevier, 2013-12)
Cystic ovarian disease (COD), which is considered one of the most important causes of reproductive failure in dairy cattle, induces intraovarian changes in the expression of numerous genes. The purpose of this study was ...