info:eu-repo/semantics/article
Neonatal exposure to bisphenol A or diethylstilbestrol alters the ovarian follicular dynamics in the lamb
Fecha
2011-11Registro en:
Rivera, Oscar Edgardo; Varayoud, Jorgelina Guadalupe; Rodríguez, Angel Horacio; Muñoz de Toro, Monica Milagros; Luque, Enrique Hugo; Neonatal exposure to bisphenol A or diethylstilbestrol alters the ovarian follicular dynamics in the lamb; Pergamon-Elsevier Science Ltd; Reproductive Toxicology; 32; 3; 11-2011; 304-312
0890-6238
CONICET Digital
CONICET
Autor
Rivera, Oscar Edgardo
Varayoud, Jorgelina Guadalupe
Rodríguez, Angel Horacio
Muñoz de Toro, Monica Milagros
Luque, Enrique Hugo
Resumen
We hypothesized that neonatal xenoestrogen exposure affects the ovarian follicular dynamics in lambs. Female lambs were exposed from postnatal day (PND) 1-14 to low doses of diethylstilbestrol (DES) or bisphenol A (BPA). At PND 30, the follicular dynamics and ovarian biomarkers (ERα, ERβ, AR, Ki67, p27) were evaluated. Lambs exposed to DES or BPA showed a decline in the stock of primordial follicles with stimulation of follicular development. BPA reduced ovarian weight and increased the number of multioocyte follicles. BPA promoted proliferation of granulosa/theca cells in antral follicles, and increased both the number of antral atretic follicles and p27 expression. Neonatal exposure to BPA or DES reduced the primordial follicle pool by stimulating their initial recruitment and subsequent follicle development until antral stage. In prepubertal lambs, the accelerated folliculogenesis resulted in increased incidence of atretic follicles. These alterations may affect the ovarian function in the adult.