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The long non-coding RNA ANRASSF1 in the regulation of alternative protein-coding transcripts RASSF1A and RASSF1C in human breast cancer cells: implications to epigenetic therapy
(2019-08-03)
Alternative protein-coding transcripts of the RASSF1 gene have been associated with dual functions in human cancer: while RASSF1C isoform has oncogenic properties, RASSF1A is a tumour suppressor frequently silenced by ...
Dynamic Activation and Repression of the Plasmodium falciparum rif Gene Family and Their Relation to Chromatin Modification
(PUBLIC LIBRARY SCIENCESAN FRANCISCO, 2012)
The regulation of variant gene expression in Plasmodium falciparum is still only partially understood. Regulation of var genes, the most studied gene family involved in antigenic variation, is orchestrated by a dynamic ...
Analysis of the methylation status of the apomixis-specific region in Paspalum spp. suggests an epigenetic control on parthenogenesis
(Oxford University Press, 2014-12)
Apomixis, a clonal plant reproduction by seeds, is controlled in Paspalum spp. by a single locus which is blocked in terms of recombination. Partial sequence analysis of the apomixis locus revealed structural features of ...
The intronic long noncoding RNA ANRASSF1 recruits PRC2 to the RASSF1A promoter, reducing the expression of RASSF1A and increasing cell proliferation
(Public Library of ScienceSan Francisco, 2013)
The down-regulation of the tumor-suppressor gene RASSF1A has been shown to increase cell proliferation in several tumors. RASSF1A expression is regulated through epigenetic events involving the polycomb repressive complex ...
Regulación genética y epigenética de la producción de IFN-γ y su asociación con la susceptibilidad a la tuberculosis
(Universidad Nacional de Quilmes, 2016-03-18)
La tuberculosis, causada por el patógeno Mycobacterium tuberculosis, a pesar de ser una enfermedad curable, continúa siendo un grave problema para la salud mundial causando altos niveles de morbilidad y mortalidad. Comprender ...
Aspectos epigenéticos del gen BTBD3 en niños diagnosticados con TDAH en una muestra de pacientes colombianos
(Universidad Nacional de Colombia - Sede Bogotá, 2018)
El TDAH es un trastorno comportamental altamente heredable, persistente y frecuente. La etiología del trastorno no está clara. Sin embargo, se han descrito similitudes neuroanatómicas entre trastorno de déficit de atención ...