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Helminths turning on the NLRP3 inflammasome: Pros and cons
(Elsevier, 2020-02)
Helminth infections can activate multimeric protein complexes called inflammasomes. In this forum we summarize the main effects of the NLRP3 inflammasome activation, including control of excessive Th2 response and ...
Intestinal microbiota modulates gluten-induced immunopathology in humanized mice
(American Society of Investigative Pathology, 2015-11)
Celiac disease (CD) is an immune-mediated enteropathy triggered by gluten in genetically susceptible individuals. The recent increase in CD incidence suggests that additional environmental factors, such as intestinal ...
Chronic inflammation as a manifestation of defects in immunoregulatory networks: implications for novel therapies based on microbial products
(Springer, 2009-07)
Based on a unifying theory presented here, it is predicted that the immune defects resulting in chronic inflammation rather than effective immune responses could be rectified by the therapeutic use of agents prepared from ...
Coeliac disease pathogenesis: The uncertainties of a well-known immune mediated disorder
(Frontiers Media, 2020-07-08)
Coeliac disease is a common small bowel enteropathy arising in genetically predisposed individuals and caused by ingestion of gluten in the diet. Great advances have been made in understanding the role of the adaptive ...
Role of aryl hydrocarbon receptor (AhR) in the regulation of immunity and immunopathology during trypanosoma cruzi infection
(Frontiers Media S.A., 2019-07)
Resistance to Trypanosoma cruzi infection is dependent on a rapid induction of Th1-type and CD8+ T cell responses that should be promptly balanced to prevent immunopathology. T. cruzi-infected B6 mice are able to control ...
PD-L2 negatively regulates Th1-mediated immunopathology during Fasciola hepatica infection
(Karger, 2016-10)
Macrophage plasticity is critical for controlling inflammation including thoseproduced by helminth infections, where alternatively activated macrophages (AAM)are accumulated in tissues. AAM expressing the co-inhibitory ...
Isolation of Neospora caninum from a beef cattle fetus from Argentina: Immunopathological and molecular studies
(Elsevier, 2020-07)
Neospora caninum is an important abortifacient agent affecting mainly cattle worldwide. The aim of the presentwork was to describe the histopathological findings in a naturally infected beef cow and its midterm fetus ...
Isolation of Neospora caninum from a beef cattle fetus from Argentina: Immunopathological and molecular studies.
(Elsevier, 2020-07)
Neospora caninum is an important abortifacient agent affecting mainly cattle worldwide. The aim of the present work was to describe the histopathological findings in a naturally infected beef cow and its midterm fetus ...
The Cholinergic System Contributes to the Immunopathological Progression of Experimental Pulmonary Tuberculosis
(Frontiers Research Foundation, 2021-02)
The cholinergic system is present in both bacteria and mammals and regulates inflammation during bacterial respiratory infections through neuronal and non-neuronal production of acetylcholine (ACh) and its receptors. ...
The influence of sex steroid hormones in the immunopathology of experimental pulmonary tuberculosis
(Public Library of Science, 2014-04)
The relation between men and women suffering pulmonary tuberculosis is 7/3 in favor to males. Sex hormones could be a significant factor for this difference, considering that testosterone impairs macrophage activation and ...