Buscar
Mostrando ítems 1-10 de 88
In vitro effect of octyl methoxycinnamate (OMC) on the release of Gn-RH and amino acid neurotransmitters by hypothalamus of adult rats
(Thieme Medical Publ Inc, 2010-07)
OMC (octyl-methoxycinnamate), an endocrine disruptor having estrogenic activity, is used in sunscreen creams as UV filter. We studied its in vitro effects on the hypothalamic release of Gn-RH as well as on the amino acid ...
One-pot biocatalyzed preparation of substituted amides as intermediates of pharmaceuticals
(Elsevier Science, 2001-01)
A lipase-catalyzed procedure is described for the one-pot conversion of carboxylic acids into substituted amides via in-situ formation of the ethyl ester and subsequent aminolysis. The procedure was optimized for the ...
The ALS gene as genetic target in CRISPR/ cas approaches: what have we learned so far?
(Crimson Publishers, 2020-08)
Specific mutations in the conserved domains of the acetolactate synthase (ALS) gene conduct to different key amino acid substitutions that can confer herbicide resistance in different plant species. This outcome has been ...
Discovery of N-Substituted 3-Amino-4-(3-boronopropyl)pyrrolidine-3-carboxylic Acids as Highly Potent Third-Generation Inhibitors of Human Arginase i and II
(American Chemical Society, 2019-08-13)
Recent efforts to identify new highly potent arginase inhibitors have resulted in the discovery of a novel family of (3R,4S)-3-amino-4-(3-boronopropyl)pyrrolidine-3-carboxylic acid analogues with up to a 1000-fold increase ...
A novel triple amino acid substitution in the EPSPS found in a high-level glyphosate-resistant Amaranthus hybridus population from Argentina
(John Wiley & Sons Ltd, 2019-05)
Background: The evolution of herbicide-resistant weeds is one of the most important concerns of global agriculture. Amaranthus hybridus L. is a competitive weed for summer crops in South America. In this article, we intend ...
Factors influencing the prevalence of resistance-associated substitutions in NS5A protein in treatment-naive patients with chronic hepatitis C
(MDPI, 2020-04)
Direct-acting antivirals (DAAs) revolutionized treatment of hepatitis C virus (HCV) infection. Resistance-associated substitutions (RASs) present at the baseline impair response to DAA due to rapid selection of resistant ...
Molecular Confirmation of the Relationship between Candida guilliermondii Fks1p Naturally Occurring Amino Acid Substitutions and Its Intrinsic Reduced Echinocandin Susceptibility
(American Society for Microbiology, 2017-05)
C. guilliermondii shows intrinsic reduced echinocandin susceptibility. It harbors two polymorphisms (L633M and T634A) at the Fks1p hot-spot 1 region. Our objective was to confirm that C. guilliermondii´s reduced echinocandin ...
Interaction of acylated and substituted antimicrobial peptide analogs with phospholipid-polydiacetylene vesicles. Correlation with their biological properties
(Wiley Blackwell Publishing, Inc, 2011-07)
A series of peptide analogs based on region 6-22 of Plantaricin 149 sequence were synthesized. The interaction between these analogs and phospholipid-polydiacetylene vesicles was investigated to evaluate the ability of the ...
Reaction between N-alkylhydroxylamines and chiral enoate esters: More experimental evidence for a cycloaddition-like process, a rationale based on DFT theoretical calculations, and stereoselective synthesis of new enantiopure β-amino acids
(American Chemical Society, 2002-12)
The reactions between N-benzyl- and N-methylhydroxylamine and chiral enoate esters, derived from D-glyceraldehyde and (-)-verbenone, respectively, have been investigated. Theoretical calculations show that the most favorable ...
Tyrosine 9 is the key amino acid in microcin J25 superoxide overproduction
(Wiley Blackwell Publishing, Inc, 2009-11)
Escherichia coli microcin J25 (MccJ25) is a lasso-peptide antibiotic comprising 21 l-amino acid residues (G1-G-A-G-H5-V-P-E-Y- F10-V-G-I-G-T15-P-I-S-F-Y20-G). MccJ25 has two independent substrates: RNA-polymerase (RNAP) ...