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Circadian regulation of gene expression: at the crossroads of transcriptional and post-transcriptional regulatory networks
(Current Biology Ltd, 2014-08)
Gene expression programs activated in response to, or in anticipation of, environmental changes involve sequential steps, from transcription and RNA processing to nuclear export and translation. Here we review recent ...
Complex networks: the key to systems biology
(Sociedade Brasileira de Genética, 2008)
Though introduced recently, complex networks research has grown steadily because of its potential to represent, characterize and model a wide range of intricate natural systems and phenomena. Because of the intrinsic ...
Filtering of data-driven gene regulatory networks using drosophila melanogaster as a case study
(Frontiers Media, 2021)
Gene Regulatory Networks (GRNs) allow the study of regulation of gene expression of whole genomes. Among the most relevant advantages of using networks to depict this key process, there is the visual representation of large ...
MicroRNA-mRNA Co-sequencing Identifies Transcriptional and Post-transcriptional Regulatory Networks Underlying Muscle Wasting in Cancer Cachexia
(Frontiers Media Sa, 2020-05-29)
Cancer cachexia is a metabolic syndrome with alterations in gene regulatory networks that consequently lead to skeletal muscle wasting. Integrating microRNAs-mRNAs omics profiles offers an opportunity to understand ...
Extensive cross-talk and global regulators identified from an analysis of the integrated transcriptional and signaling network in Escherichia coli
(ROYAL SOC CHEMISTRYCAMBRIDGE, 2012)
To understand the regulatory dynamics of transcription factors (TFs) and their interplay with other cellular components we have integrated transcriptional, protein-protein and the allosteric or equivalent interactions which ...
Integrative transcriptome analysis identifies deregulated microRNA-transcription factor networks in lung adenocarcinoma
(2016-05-17)
Herein, we aimed at identifying global transcriptome microRNA (miRNA) changes and miRNA target genes in lung adenocarcinoma. Samples were selected as training (N = 24) and independent validation (N = 34) sets. Tissues were ...
Reconstruction of regulatory network predicts transcription factors driving the dynamics of zebrafish heart regeneration
(2022-04-20)
The limited regenerative capacity in mammals has serious implications for cardiac tissue damage. Meanwhile, zebrafish has a high regenerative capacity, but the regulation of the heart healing process has yet to be elucidated. ...
Cross-Species Network Analysis Uncovers Conserved Nitrogen-Regulated Network Modules in Rice
(American Society of Plant Biologist, 2015-08)
In this study, we used a cross-species network approach to uncover nitrogen-regulated network modules conserved across a model and a crop species. By translating gene “network knowledge” from the data-rich model Arabidopsis ...
Emerging roles of ATF2 and the dynamic AP1 network in cancer
(Nature Publishing Group, 2010-01)
Cooperation among transcription factors is central for their ability to execute specific transcriptional programmes. The AP1 complex exemplifies a network of transcription factors that function in unison under normal ...