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Daily very low UV dose exposure enhances adaptive immunity, compared with a single high‐dose exposure. Consequences for the control of a skin infection
(Wiley Blackwell Publishing, Inc, 2018-07)
Ultraviolet radiation (UVr) promotes several well‐known molecular changes, which may ultimately impact on health. Some of these effects are detrimental, like inflammation, carcinogenesis and immunosuppression. On the other ...
Pharmacokinetics and skin concentrations of lincomycin after intravenous and oral administration to cats
(South African Veterinary Association, 2013-10)
The aim of the present study was to describe the plasma pharmacokinetic profile and skin concentrations of lincomycin after intravenous administration of a 15% solution and oral administration of 300 mg tablets at a dosing ...
Bioevaluation of 32P patch designed for the treatment of skin diseases
(Elsevier Science Inc., 2008-02)
Objective: The objective of this study was to design and evaluate a 32P patch for the treatment of skin diseases. Materials and Methods: The patch was prepared from chromic phosphate 32P and silicone. Bioelimination and ...
Time-course study of different innate immune mediators produced by ultraviolet irradiated skin. Comparative effects between short and daily versus harmful and imprudent UV- exposures
(Wiley, 2014-11)
The modulatory effects of solar ultraviolet radiation (UVR) on the immune system have been widely studied. As the skin is the main target of UVR, our purpose was to compare the impact of two contrasting ways to be exposed ...
The topical nanodelivery of vismodegib enhances its skin penetration and performance in vitro while reducing its toxicity in vivo
(Multidisciplinary Digital Publishing Institute, 2021-01)
Vismodegib is a first-in-class inhibitor for advanced basal cell carcinoma treatment. Its daily oral doses present a high distribution volume and several side effects. We evaluated its skin penetration loaded in diverse ...
Biological effects of brachytherapy using a 32P-patch on the skin of Sencar mice
(Pergamon-Elsevier Science Ltd, 2009-10)
In recent years, specially designed patches containing beta emitters have been developed for contact brachytherapy of skin lesions. The aim of the present work was to evaluate the biological effects of the 32P-patch on the ...
Intake of oral photoprotectors by postmen in Porto Alegre
(HCPA/FAMED/UFRGS, 2017)
L-ascorbic acid alkyl esters action on stratum corneum model membranes: an insight into the mechanism for enhanced skin permeation
(Elsevier Science, 2019-11)
L-ascorbic acid alkyl esters (ASCn) are lipophilic forms of vitamin C, which act as skin permeation enhancers. We investigated the physical changes induced by incorporating ASCn into stratum corneum (SC) lipid membranes ...
Clinical factors affecting the determination of radiotherapy-induced skin toxicity in breast cancer
(Korean Society for Radiation Oncology, 2021-12)
Purpose:Radiotherapy is essential for the treatment of breast cancer (BC). However, adverse effects may occur in healthy tissue, during treatment and even after several months. Although it is known that this clinical ...
Biochemical characterization and cytotoxic effect of the skin secretion from the red-spotted Argentina frog Argenteohyla siemersi (Anura: Hylidae)
(Cevap-unesp, 2020-03)
Background: Argenteohyla siemersi (red-spotted Argentina frog) is a casque-headed tree frog species belonging to the Hylidae family. This species has a complex combination of anti-predator defense mechanisms that include ...