info:eu-repo/semantics/article
Daily very low UV dose exposure enhances adaptive immunity, compared with a single high‐dose exposure. Consequences for the control of a skin infection
Fecha
2018-07Registro en:
Cela, Eliana Maiten; Gonzalez, Cintia Daniela; Friedrich, Adrián David; Ledo, Camila; Paz, Mariela Laura; et al.; Daily very low UV dose exposure enhances adaptive immunity, compared with a single high‐dose exposure. Consequences for the control of a skin infection; Wiley Blackwell Publishing, Inc; Immunology; 154; 3; 7-2018; 510-521
0019-2805
CONICET Digital
CONICET
Autor
Cela, Eliana Maiten
Gonzalez, Cintia Daniela
Friedrich, Adrián David
Ledo, Camila
Paz, Mariela Laura
Leoni, Juliana
Gomez, Marisa Ines
Gonzalez Maglio, Daniel Horacio
Resumen
Ultraviolet radiation (UVr) promotes several well‐known molecular changes, which may ultimately impact on health. Some of these effects are detrimental, like inflammation, carcinogenesis and immunosuppression. On the other hand, UVr also promotes vitamin D synthesis and other beneficial effects. We recently demonstrated that exposure to very low doses of UVr on four consecutive days [repetitive low UVd (rlUVd)] does not promote an inflammatory state, nor the recruitment of neutrophils or lymphocytes, as the exposure to a single high UV dose (shUVd) does. Moreover, rlUVd reinforce the epithelium by increasing antimicrobial peptides transcription and epidermal thickness. The aim of this study was to evaluate the adaptive immune response after shUVd and rlUVd, determining T‐cell and B‐cell responses. Finally, we challenged animals exposed to both irradiation procedures with Staphylococcus aureus to study the overall effects of both innate and adaptive immunity during a cutaneous infection. We observed, as expected, a marked suppression of T‐cell and B‐cell responses after exposure to an shUVd but a novel and significant increase in both specific responses after exposure to rlUVd. However, the control of the cutaneous S. aureus infection was defective in this last group, suggesting that responses against pathogens cannot be ruled out from isolated stimuli.