Now showing items 1-10 of 1633
New trends in organic synthesis with oxidative enzymes
(Bentham Science Publishers, 2012-08)
Oxidative enzymes constitute privileged catalysts in organic synthesis. Environmentally benign reaction conditions along with high selectivity are the most appealing characteristic shown by these biocatalysts in contrast ...
pH regulation of enzyme production in Aspergillus nidulans growing in aerobic batch fermenter
The physiological response to ambient pH on the regulation of the production of the xylanolytic enzyme complex was investigated using two modified strains of Aspergillus nidulans. Transcriptional gene fusions were constructed ...
Effects of experimental intracerebral ventricular injection of amyloid beta peptide (1-42) aggregates on daily rhythms of Aβ-degrading enzymes in the hippocampus: Relevance to Alzheimer's disease pathophysiology
One of the main pathological features in the Alzheimer disease (AD) is the presence of senile plaques, primarily composed of Aβ peptide aggregates, in cortex and hippocampus. AD late onset, which constitutes 90% of cases, ...
Evolutionary coupling range varies widely among enzymes depending on selection pressure
(Cell Press, 2021-10-19)
Recent studies proposed that enzyme-active sites induce evolutionary constraints at long distances. The physical origin of such long-range evolutionary coupling is unknown. Here, I use a recent biophysical model of evolution ...
Enzyme Induction and Drug Metabolism
(Springer Nature Switzerland AG, 2021)
Enzyme induction is one of the most important underlying mechanism of drug-drug interactions (DDIs). It can be defined as an increase in the biosynthesis of metabolizing enzymes after the exposure of the organism to ...
Magneto-mechanical model of an enzyme
(Springer Verlag Berlín, 2002-12)
It has always been difficult to clearly explain to biochemistry students how enzymes work. The idea of enzymeñsubstrate stereospecificity, active site, coupled reactions, inhibitor or activator effects, mono- and bisubstrate ...
Molecular recognition of an acyl-enzyme intermediate on the lipase B from Candida antarctica
(Royal Society of Chemistry, 2017-03-28)
This investigation provides evidences of the acyl enzyme species involved in theinteraction of R/S-ketoprofen with the lipase B from Candida antarctica. The interaction between the profen and the enzyme was studied by in ...
Restriction Enzymes in Microbiology, Biotechnology and Biochemistry
(Universidad Centroamericana, 2012)
β-cyclodextrin modifications as related to enzyme stability in dehydrated systems: Supramolecular transitions and molecular interactions
The effect of β-cyclodextrin modifications (polymerization (PCD) and later carboxymethylation (CMPCD)) on their action as enzyme stabilizers was analyzed during freeze-drying and thermal treatment. Combined polymer-trehalose ...
Immobilized enzymes and their applications
The aim of enzyme immobilization is to develop a robust biocatalyst able to work under inonnative and harsh operational conditions with an extended lifetime. Biocatalyst immobilization can be defined as physical confinement ...