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Renaissance of Allostery to Disrupt Protein Kinase Interactions
(Elsevier Science London, 2019-11)
Protein–protein interactions often regulate the activity of protein kinases by allosterically modulating the conformation of the ATP-binding site. Bidirectional allostery implies that reverse modulation (i.e., from the ...
Intrinsic disorder associated with 14-3-3 proteins and their partners
(Elsevier, 2019-01)
Protein-protein interactions (PPIs) mediate a variety of cellular processes and form complex networks, where connectivity is achieved owing to the “hub” proteins whose interaction with multiple protein partners is facilitated ...
Aromatic clusters in protein-protein and protein-drug complexes
(BioMed Central, 2020-05)
Aromatic rings are important residues for biological interactions and appear to a large extent as part of protein-drug and protein-protein interactions. They are relevant for both protein stability and molecular recognition ...
Important aspects in the knowledge of protein–lipid interactions from 1900 up to 2017
(Nova Science Publishers, 2018)
In the last five decades, the significance of protein-lipid interactions in biological systems began to be widely explored; the most important hand marks in the knowledge of protein-lipid interactions from 1969 up to now ...
Deposition of Foreign Proteins in Plant Vacuoles: A Unique Characteristic of Plant-Based Platforms
(Nova Science Publishers, 2019)
The global demand for biological and industrial enzymes is growing driven by the increasing world population and the expansion of their biotechnological applications. To be active and soluble, many of these proteins require ...
Chasing coevolutionary signals in intrinsically disordered proteins complexes
(Nature, 2020-10)
Intrinsically disordered proteins/regions (IDPs/IDRs) are crucial components of the cell, they are highly abundant and participate ubiquitously in a wide range of biological functions, such as regulatory processes and cell ...
Protein Repeats from First Principles
(Nature Publishing Group, 2016-04)
Some natural proteins display recurrent structural patterns. Despite being highly similar at the tertiary structure level, repeating patterns within a single repeat protein can be extremely variable at the sequence level. ...
AMINO ACID CONTENT AND NUTRITIVE VALUE OF TUNA (THUNNUS SP.) FISHMEALS RELATIVE TO THEIR CRUDE-PROTEIN CONTENTAMINO ACID CONTENT AND NUTRITIVE VALUE OF TUNA (THUNNUS SP.) FISHMEALS RELATIVE TO THEIR CRUDE-PROTEIN CONTENT
(University of Puerto Rico Mayagüez Campus Agricultural Experiment Station, 1970)
Deep Learning to Therapeutically Target Unreported Complexes
(Elsevier Science London, 2019-05-21)
The disruption of large protein–protein (PP) interfaces remains a challenge in targeted therapy. Designing drugs that compete with binding partners is daunting, especially when the structure of the protein complex is ...
Ophioviruses CPsV and MiLBVV movement protein is encoded in RNA2 and interacts with the coat protein
(Academic Press Inc Elsevier Science, 2013-07)
Citrus psorosis virus (CPsV) and Mirafiori lettuce big-vein virus (MiLBVV), members of the Ophioviridae family, have segmented negative-sense single-stranded RNA genomes. To date no reports have described how ophioviruses ...