info:eu-repo/semantics/article
Renaissance of Allostery to Disrupt Protein Kinase Interactions
Fecha
2019-11Registro en:
Leroux, Alejandro Ezequiel; Biondi, Ricardo Miguel; Renaissance of Allostery to Disrupt Protein Kinase Interactions; Elsevier Science London; Trends In Biochemical Sciences; 45; 1; 11-2019; 27-41
0968-0004
CONICET Digital
CONICET
Autor
Leroux, Alejandro Ezequiel
Biondi, Ricardo Miguel
Resumen
Protein–protein interactions often regulate the activity of protein kinases by allosterically modulating the conformation of the ATP-binding site. Bidirectional allostery implies that reverse modulation (i.e., from the ATP-binding site to the interaction and regulatory sites) must also be possible. Here, we review both the allosteric regulation of protein kinases and recent work describing how compounds binding at the ATP-binding site can promote or inhibit protein kinase interactions at regulatory sites via the reverse mechanism. Notably, the pharmaceutical industry has been developing compounds that bind to the ATP-binding site of protein kinases and potently disrupt protein–protein interactions between target protein kinases and their regulatory interacting partners. Learning to modulate allosteric processes will facilitate the development of protein–protein interaction modulators.
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