Buscar
Mostrando ítems 1-10 de 215
Progesterone effects on the oligodendrocyte linage: all roads lead to the progesterone receptor
(Shenyang Editorial Dept Neural Regeneration Res, 2019-12)
A new role has emerged for progesterone after discovering its potent actions away from reproduction in both the central and the peripheral nervous system. The aim of the present report is to discuss progesterone’s mechanisms ...
Molecular mechanisms underlying progesterone receptor action in breast cancer: Insights into cell proliferation and stem cell regulation
(Elsevier Science Inc, 2019-12)
The ovarian steroid hormone progesterone and its nuclear receptor, the Progesterone Receptor (PR), play an essential role in the regulation of cell proliferation and differentiation in the mammary gland. In addition, ...
Targeting progesterone receptors in breast cancer
(Elsevier Academic Press Inc, 2013)
Hormone receptors represent the earliest biomarkers used in breast cancer not only as prognosis markers but, in addition, to decide treatment. However, mostly estrogen receptors have been used as therapeutic targets. There ...
Progesterone and progestins: neuroprotection and myelin repair
(Elsevier, 2008-12)
Progesterone, known for its role in pregnancy, also exerts marked effects on the nervous system. Its neuroprotective and promyelinating actions, now well documented by experimental studies, make it a particularly promising ...
Effects of injury and progesterone treatment on progesterone receptor and progesterone binding protein 25-Dx expression in the rat spinal cord
(Wiley Blackwell Publishing, Inc, 2003-09)
Progesterone provides neuroprotection after spinal cord injury, but the molecular mechanisms involved in this effect are not completely understood. In this work, expression of two binding proteins for progesterone was ...
New insights into progesterone actions on prolactin secretion and prolactinoma development
(Elsevier Science Inc., 2019-09-12)
Progesterone (P4) has controversial physiological effects on the regulation of the lactotroph population. While some studies have shown a negative role for P4 in prolactin secretion and lactotroph proliferation, antagonizing ...
Revisiting progesterone receptor (PR) actions in breast cancer: Insights into PR repressive functions
(Elsevier Science Inc, 2018-05)
Progesterone receptor (PR) is a master regulator in female reproductive tissues that controls developmental processes and proliferation and differentiation during the reproductive cycle and pregnancy. PR also plays a role ...
The hyperplastic phenotype in PR-A and PR-B transgenic mice: lessons on the role of estrogen and progesterone receptors in the mouse mammary gland and breast cancer.
(Elsevier, 2013)
Progesterone receptor (PR) belongs to the superfamily of steroid receptors and mediates the action of progesterone in its target tissues. In the mammary gland, in particular, PR expression is restricted to the luminal ...
Progesterone and breast
(Bailliere Tindall, 2020-04)
Progesterone (Pg) is a pregnancy-related hormone that prepares the endometrium for the implantation of the fertilized zygote and suppresses myometrial contractility for the maintenance of pregnancy. At high concentrations, ...
Progesterone receptors in normal breast development and breast cancer
(Portland Press, 2021-06)
Progesterone receptors (PR) play a pivotal role in many female reproductive tissues such as the uterus, the ovary, and the mammary gland (MG). Moreover, PR play a key role in breast cancer growth and progression. This has ...