info:eu-repo/semantics/article
Progesterone receptors in normal breast development and breast cancer
Date
2021-06Registration in:
Giulianelli, Sebastian Jesus; Lamb, Caroline Ana; Lanari, Claudia Lee Malvina; Progesterone receptors in normal breast development and breast cancer; Portland Press; Essays In Biochemistry; 6-2021
0071-1365
1744-1358
CONICET Digital
CONICET
Author
Giulianelli, Sebastian Jesus
Lamb, Caroline Ana
Lanari, Claudia Lee Malvina
Abstract
Progesterone receptors (PR) play a pivotal role in many female reproductive tissues such as the uterus, the ovary, and the mammary gland (MG). Moreover, PR play a key role in breast cancer growth and progression. This has led to the development and study of different progestins and antiprogestins, many of which are currently being tested in clinical trials for cancer treatment. Recent reviews have addressed the role of PR in MG development, carcinogenesis, and breast cancer growth. Thus, in this review, in addition to making an overview on PR action in normal and tumor breast, the focus has been put on highlighting the still unresolved topics on hormone treatment involving PR isoforms and breast cancer prognosis.