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Effect of the protein corona on the colloidal stability and reactivity of LDH-based nanocarriers
(Royal Society of Chemistry, 2016-03-15)
The physicochemical properties of drug nanocarriers such as layered double hydroxide nanoparticles (LDH-NPs) determine their circulation times in biological media and their interaction with the targeted cells. Nevertheless, ...
One Pot Epoxide-Driven Synthesis of M2Al(OH)6Cl 1.5H2O Layered Double Hydroxides: Precipitation Mechanism and Relative Stabilities
(American Chemical Society, 2014-12)
A family of single-crystalline particles of M2Al(OH)6Cl·1.5H2O layered double hydroxides (LDH) with M(II) a transition-metal cation were obtained by a one-pot room-temperature homogeneous alkalinization driven by glycidol ...
Interplay of charge density and relative humidity on the structure of nitrate layered double hydroxides
(American Chemical Society, 2010-10)
The structure of several crystalline Ni(II)-Al(III) and Mg(II)-Al(III) layered double hydroxides (LDHs) intercalated with nitrate anions was studied as a function of the relative humidity. For low charge density LDHs, the ...
Structural and morphological aspects of (fluoro) quinolone delivery by layered double hydroxide nanoparticles
(Royal Society of Chemistry, 2018-10-31)
Layered double hydroxides (LDHs) have been proposed as delivery systems (DSs) of (fluoro)quinolones (QLNs) to overcome their low bioavailability and to prevent the emergence of resistant bacteria. Both LDH-DS synthesis as ...
A closer look into the physical interactions between lipid membranes and layered double hydroxide nanoparticles
(Elsevier Science, 2020-07)
Layered double hydroxide nanoparticles (LDH-NPs) constitute promising nanocarriers for drug and gene delivery. Although their cell internalization has been studied, the interaction between LDH-NPs and biological membrane ...
Layered double hydroxide nanoparticles customization by polyelectrolyte adsorption: mechanism and effect on particle aggregation
(Elsevier Science, 2017-11)
Adsorption of polyelectrolytes (PEs) is a common strategy for stabilizing nanoparticles and customizing their properties. Although scarcely explored for layered double hydroxide nanoparticles (LDH-NPs), it can be used to ...
Synthetic and biological identities of layered double hydroxides nanocarriers functionalized with risedronate
(Elsevier Science, 2020-12-01)
Layered double hydroxide nanoparticles (LDH-NP) provide new therapeutic opportunities to improve drug distribution, stability, and effectivity. Nevertheless, these LDH-NP present a different behavior in biological medium ...
Risedronate functionalized layered double hydroxides nanoparticles with bone targeting capabilities
(Elsevier Science, 2017-06-01)
Layered double hydroxides nanoparticles (LDH-NPs) are increasingly studied as drug nanocarriers for cellular delivery. Nevertheless, stable functionalizations providing targeting capabilities without disrupting the size ...
Uptake/release of vancomycin on/from Mg–Al layered double hydroxides
(Springer, 2019-04)
For several decades antimicrobial resistance has been a growing threat to the efective treatment of infections, so it is necessary to focus on a rational and efective use of the antibiotics already available. The development ...
Ciprofloxacin-intercalated layered double hydroxide-in-hybrid films as composite dressings for controlled antimicrobial topical delivery
(Elsevier Science, 2020-06)
Films based on biopolymers and loaded with antimicrobial agents are convenient pharmaceutical dosage forms for topical application. Inorganic carriers loaded with these agents lead to composite materials, which combined ...