Buscar
Mostrando ítems 1-10 de 102
Lack of efficacy of standard doses of ivermectin in severe COVID-19 patients
(Public Library of Science, 2020-11)
Ivermectin has recently shown efficacy against SARS-CoV-2 in-vitro. We retrospectively reviewed severe COVID-19 patients receiving standard doses of ivermectin and we compared clinical and microbiological outcomes with a ...
Tissue depletion profile of ivermectin in rabbits
(ECronicon, 2020-07-11)
Avermectins are largely used in different animal species. Ivermectin, the most popular avermectin, is used against a wide spectrum of endo and ectoparasites. Some mange mites are particularly sensitive to ivermectin. ...
Failure of ivermectin and eprinomectin to control Amblyomma parvum in goats: Characterization of acaricidal activity and drug pharmacokinetic disposition
(Elsevier Science, 2008-10)
The therapeutic efficacies of ivermectin (subcutaneous injection) and eprinomectin (topical treatment) given at two different dosage levels to goats naturally infested with Amblyomma parvum were assessed. Treatments included ...
Route of administration influences the concentration of ivermectin reaching nematode parasites in the gastrointestinal tract of cattle
(Elsevier, 2020-12)
An animal trial was conducted to measure the concentrations of ivermectin occurring in abomasal and small intestinal contents and mucosa, and in the target parasites (Ostertagia ostertagi and Cooperia oncophora) following ...
Sex-related differences in the gastrointestinal disposition of ivermectin in the rat: P-glycoprotein involvement and itraconazole modulation
(Pharmaceutical Press-Royal Pharmaceutical Society Great Britian, 2006-08)
Ivermectin (IVM), a macrocyclic lactone used as antiparasite agent, has been reported as a P‐glycoprotein (P‐gp) substrate. The participation of P‐gp in the IVM excretion process has been previously demonstrated. Sex‐related ...
Influence of the cattle body weight estimation for drug dosing on the pharmacokinetic and efficacy of ivermectin against Rhipicephalus (Boophilus) microplus
(Systematic and Applied Acarology Society, 2022-08)
This study aimed to evaluate how the method of body weight estimation of a herd (average vs individual) for drug dosing may affect the pharmacokinetics and therapeutic efficacy of ivermectin 3.15% against Rhipicephalus ...
Development of a Minimal Physiologically-Based Pharmacokinetic Model to Simulate Lung Exposure in Humans Following Oral Administration of Ivermectin for COVID-19 Drug Repurposing
(Elsevier, 2020-12-01)
SARS-CoV-2 utilizes the IMPα/β1 heterodimer to enter host cell nuclei after gaining cellular access through the ACE2 receptor. Ivermectin has shown antiviral activity by inhibiting the formation of the importin-α (IMPα) ...
Safety and efficacy of a MEURI Program for the use of high dose Ivermectin in COVID-19 patients
(Frontiers Media, 2022-02)
Background: In the absence of antiviral alternatives, interventions under research for COVID-19 might be offered following guidelines from WHO for monitored emergency use of unregistered and experimental interventions ...
Relationship between pharmacokinetics of ivermectin (3.15%) and its efficacy to control the infestation with the tick Rhipicephalus (Boophilus) microplus in cattle
(Elsevier Science, 2019-04)
This study aimed to determine the relationship between the variation in plasma concentration of ivermectin<br />3.15% over time and its efficacy against the cattle tick Rhipicephalus (Boophilus) microplus. In addition, a ...
Resistance induced changes on triclabendazole transport in Fasciola hepatica: ivermectin reversal effect
(American Society of Parasitologists, 2006-12)
Triclabendazole (TCBZ) and albendazole (ABZ) are flukicidal benzimidazole compounds extensively used in veterinary medicine. Although TCBZ has excellent activity against mature and immature stages of the liver fluke, ...