info:eu-repo/semantics/article
Relationship between pharmacokinetics of ivermectin (3.15%) and its efficacy to control the infestation with the tick Rhipicephalus (Boophilus) microplus in cattle
Fecha
2019-04Registro en:
Nava, Santiago; Rossner, María; Ballent, Mariana; Mangold, Atilio Jose; Lanusse, Carlos Edmundo; et al.; Relationship between pharmacokinetics of ivermectin (3.15%) and its efficacy to control the infestation with the tick Rhipicephalus (Boophilus) microplus in cattle; Elsevier Science; Veterinary Parasitology; 268; 4-2019; 81-86
0304-4017
CONICET Digital
CONICET
Autor
Nava, Santiago
Rossner, María
Ballent, Mariana
Mangold, Atilio Jose
Lanusse, Carlos Edmundo
Lifschitz, Adrian Luis
Resumen
This study aimed to determine the relationship between the variation in plasma concentration of ivermectin<br />3.15% over time and its efficacy against the cattle tick Rhipicephalus (Boophilus) microplus. In addition, a trial was<br />conducted to infer if the application of successive treatments with ivermectin 3.15% could affect its accumulation<br />in cattle. A noticeable variation of ivermectin plasma concentration was observed among the treated<br />heifers. However, these differences did not have a significant effect onthe therapeutic efficacy of the treatment at<br />the end of the trial. No significant differences were observed in the levels of tick infestations between heifers of<br />the treated group; moreover, no significant correlation was detected between the plasma AUC0-21 of ivermectin<br />3.15% and the cumulative number of ticks of each heifer. Levels of therapeutic efficacy higher than 80% were<br />observed only from day 7 post-treatment, when levels of ivermectin concentration were higher than 8 ng/ml.<br />The lowest values of therapeutic efficacy were observed during the first and the second days post-treatment,<br />when plasma concentrations of ivermectin 3.15% were lower than 8 ng/ml. Viable engorged females were<br />collected from the heifers belonging to the treated group from days 1?5 post-treatment. There was a significant<br />accumulation of the drug after the second dose of ivermectin 3.15%. Ivermectin concentrations in fat biopsies<br />were 366 ng/g (51 days after the first treatment), 275 ng/g (51 days after the second treatment) and 15 ng/g (64<br />days after the second treatment). These results suggest that applications of successive treatments with ivermectin<br />3.15% might increase its accumulation in cattle tissues, extending the withdrawal period indicated for the<br />commercial formulation.