Buscar
Mostrando ítems 1-10 de 160
Making Targeted Therapy Compatible with Checkpoint Immunotherapy
(Elsevier Science London, 2017-07)
Immune checkpoint blockades induced by antibodies are revolutionizing cancer therapy. Combinations of checkpoint immunotherapies with kinase inhibitors (KIs) are being clinically evaluated as oncogenic mutations arise. ...
Recent advances and future of immunotherapy for glioblastoma
(Informa Healthcare, 2016-10)
Introduction: Outcome for glioma (GBM) remains dismal despite advances in therapeutic interventions including chemotherapy, radiotherapy and surgical resection. The overall survival benefit observed with immunotherapies ...
Current state and future prospects of immunotherapy for glioma
(Future Medicine, 2018-03)
There is a large unmet need for effective therapeutic approaches for glioma, the most malignant brain tumor. Clinical and preclinical studies have enormously expanded our knowledge about the molecular aspects of this deadly ...
Imiquimod-loaded nanoarchaeosomes as a promising immunotherapy against Trypanosoma cruzi infection
(Elsevier Science, 2020-05)
The purpose of this study was to evaluate the efficacy of imiquimod-containing nanovesicles prepared with lipids extracted from the hyperhalophile archaebacterium Halorubrum tebenquichense (nanoARC-IMQ) to induce protection ...
An integrative model of cancer cell differentiation with immunotherapy
(IOP Publishing, 2021-10)
In order to improve cancer treatments, cancer cell differentiation and immunotherapy are the subjects of several studies in different branches of interdisciplinary sciences. In this work, we develop a new population model ...
Engineering tumor hypersusceptibility to checkpoint immunotherapy
(Cell Press, 2017-09-04)
The immune checkpoint blockerpembrolizumab(Keytruda)hasproven successful in treating solidtumors harboring a DNA mismatchrepair (MMR) deficiency. We showthat it is possible to generate adrug-promoted phenotype mim-icking ...
Going Forward with Lymphocytes Immunotherapies for Treatment of Unexplained Recurrent Spontaneous Abortion
(BiomedGrid, 2019-12)
Recurrent spontaneous abortion (RSA), defined as the occurrence of two or more consecutive miscarriages at less than 22-weeks of gestation [1], is one of the major pregnancy disorders and affects up to 5% of couples of ...
Immunomodulatory monoclonal antibodies in combined immunotherapy trials for cutaneous melanoma
(Frontiers Media S.A., 2017-08)
In the last few years, there has been a twist in cancer treatment toward immunotherapy thanks to the impressive results seen in advanced patients from several tumor pathologies. Cutaneous melanoma is a highly mutated and ...
Direct validation of NGcGM3 ganglioside as a new target for cancer immunotherapy
(Informa Healthcare, 2009-12)
OBJECTIVE: The target concept means not only an aberrant expression of a particular molecule in tumour tissues but also evidence of a clear therapeutic advantage, as a consequence of immune-intervention, in an antigen-positive ...
CD40 activation of BCP-ALL cells generates IL-10-producing, IL-12-defective APCs that induce allogeneic T-cell anergy
(American Society of Hematology, 2004-12)
The use of leukemia cells as antigenpresenting cells (APCs) in immunotherapy is critically dependent on their capacity to initiate and sustain an antitumor-specific immune response. Previous studies suggested that pediatric ...