info:eu-repo/semantics/article
Imiquimod-loaded nanoarchaeosomes as a promising immunotherapy against Trypanosoma cruzi infection
Fecha
2020-05Registro en:
Parra, Federico Leonel; Frank, Fernanda María; Alliani, Bruno Fernando; Romero, Eder Lilia; Petray, Patricia Beatriz; Imiquimod-loaded nanoarchaeosomes as a promising immunotherapy against Trypanosoma cruzi infection; Elsevier Science; Colloids and Surfaces B: Biointerfaces; 189; 5-2020; 1-9
0927-7765
CONICET Digital
CONICET
Autor
Parra, Federico Leonel
Frank, Fernanda María
Alliani, Bruno Fernando
Romero, Eder Lilia
Petray, Patricia Beatriz
Resumen
The purpose of this study was to evaluate the efficacy of imiquimod-containing nanovesicles prepared with lipids extracted from the hyperhalophile archaebacterium Halorubrum tebenquichense (nanoARC-IMQ) to induce protection against Trypanosoma cruzi infection. The therapeutic efficacy of archaeolipid nanovesicles was assessed in an experimental murine model of acute infection with T. cruzi. The administration of nanoARQ-IMQ prevented mortality as compared to infected untreated animals, reduced parasitemia levels and diminished myocardial and musculoskeletal lesions in mice infected with a lethal strain of T. cruzi. Our findings suggest that the immunotherapy with nanoARC-IMQ has potential to limit the progression of Chagas disease.