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Uncoupling of actomyosin adenosinetriphosphatase by heparin and its fragments
(Springer, 1997-04-01)
Heparin and its enzymatic fragments, prepared by degradation of heparin with heparinase from Flavo-bacterium heparinum, were capable of inhibiting the actomyosin-ATPase activity obtained from striated and smooth vascular ...
The interaction between heparin and Lys49 phospholipase A(2) reveals the natural binding of heparin on the enzyme
(Elsevier B.V., 2005-10-30)
We have studied at a molecular level the interaction of heparins on bothropstoxin-1 (BthTx-1), a phospholipase A(2) toxin. The protein was monitored using gel filtration chromatography, dynamic light scattering (DLS), ...
Cathepsin X binds to cell surface heparan sulfate proteoglycans
(Elsevier B.V., 2005-04-15)
Glycosaminoglycans have been shown to be important regulators of activity of several papain-like cathepsins. Binding of glycosaminoglycans to cathepsins thus directly affects catalytic activity, stability or the rate of ...
Lepstospira interrogans shotgun phage display identified LigB as a heparin-binding protein
(Elsevier B.V., 2012-11-02)
LigB is an adhesin from pathogenic Leptospira that is able to bind to extracellular matrix and is considered a virulence factor. A shotgun phage display genomic library was constructed and used for panning against Heparan ...
Heparin-binding proteins of canine seminal plasma
(Elsevier B.V., 2006-10-01)
Heparin-binding proteins (HBP) from seminal plasma have been expected to participate in modulation of the acrosomal reaction, and have been correlated with fertility in some species. However, they have not been described ...
DNA and heparin chaperone the refolding of purified recombinant replication protein A subunit 1 from Leishmania amazonensis
(Elsevier B.V., 2009-02-01)
Replication protein A (RPA) is a single-stranded DNA-binding protein that has been implicated in DNA metabolism and telomere maintenance. Subunit 1 of RPA from Leishmania amazonensis (LaRPA-1) has previously been ...
Heparin and a cyclic octaphenol-octasulfonic acid (GL-522-Y-1) bind with high affinity to a 47-kDa protein from vascular endothelial cell surface and stimulate the synthesis and structural changes of heparan sulfate proteoglycan
(Elsevier B.V., 2001-07-01)
The effect of a cyclic octaphenol-octasulfonic acid (GL-522-Y-1), upon the synthesis of a heparan sulfate proteoglycan synthesized by endothelial cells (rabbit aorta and human umbilical vein) were studied. the cells were ...
Heparin binding proteins from Leishmania (Viannia) braziliensis promastigotes
(Elsevier B.V., 2007-04-30)
We have examined the heparin binding proteins from Leishmania (Viannia) braziliensis promastigotes (HBP-Lb) by chromatography assays. the proposed strategy to isolate an enriched fraction of the HBP-Lb consisted of an ...
Internalization and degradation of heparin is not required for stimulus of heparan sulfate proteoglycan synthesis
(Wiley-Blackwell, 2008-11-01)
In vitro, heparin and antithrombotic drugs specifically stimulate the synthesis of an antithrombotic heparan sulfate proteoglycan (HSPG) produced by endothelial cells. the putative heparin binding site(s) that may be related ...
Proteinase activity regulation by glycosaminoglycans
(Associação Brasileira de Divulgação Científica, 2002-02-01)
There are few reports concerning the biological role and the mechanisms of interaction between proteinases and carbohydrates other than those involved in clotting. It has been shown that the interplay of enzymes and ...