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Galectin-1 functions as a Th2 cytokine that selectively induces Th1 apoptosis and promotes Th2 function
(Wiley VCH Verlag, 2008-11)
Galectin-1 has been implicated in regulating T-cell survival, function, and Th1/Th2 balance in several mouse models, though the molecular and cellular basis of its immunomodulatory activity has not been completely ...
Galectin-Levels Are Elevated in Infants Born Preterm Due to Amniotic Infection and Rapidly Decline in the Neonatal Period
(Frontiers Media, 2021-02-25)
Galectin (gal)-1, -3, and -9 are members of a family of glycan binding proteins that mediate complex interactions between decidual, inflammatory and trophoblast cells modulating several processes during gestation, control ...
A novel function for galectin-1 at the crossroad of innate and adaptive immunity: galectin-1 regulates monocyte/macrophage physiology through a nonapoptotic ERK-dependent pathway
(American Association of Immunologists, 2007-01-01)
Several environmental factors can differentially regulate monocyte and macrophage response patterns, resulting in the display of distinct functional phenotypes. Galectin-1, an endogenous lectin found at peripheral lymphoid ...
Galectin-1 suppresses experimental colitis in mice
(American Gastroenterological Association, 2003-05)
Uncontrolled T-cell activation plays a critical role in the pathogenesis of inflammatory bowel diseases. Therefore, pharmacologic strategies directed to restore the normal responsiveness of the immune system by deleting ...
Unlocking the secrets of galectins: a challenge at the frontier of glyco-immunology
(Federation of American Societies for Experimental Biology, 2002-05)
Over the last decade, we have witnessed an explosion of information regarding the function of glycoconjugates, carbohydrate-binding proteins, and the elucidation of the sugar code. This progress has yielded not only important ...
An integrated computational analysis of the structure, dynamics, and ligand binding interactions of the human galectin network
(American Chemical Society, 2011-08)
Galectins, a family of evolutionarily conserved animal lectins, have been shown to modulate signaling processes leading to inflammation, apoptosis, immunoregulation, and angiogenesis through their ability to interact with ...
Galectins as checkpoints of the immune system in cancers, their clinical relevance, and implication in clinical trials
(Molecular Diversity Preservation International, 2020-05)
Galectins are small proteins with pleiotropic functions, which depend on both their lectin (glycan recognition) and non-lectin (recognition of other biomolecules besides glycans) interactions. Currently, 15 members of this ...
Protein-glycan interactions in immunoregulation: galectins as tuners of the inflammatory response
(Scion Publishing Ltd, 2007)
Protein-glycan interactions mediate a variety of biological processes including cell trafficking, activation, differentiation, and survival. Galectins, a growing family of animal lectins defined by shared consensus amino ...
Impact of Galectins in Resistance to Anticancer Therapies
(American Association for Cancer Research, 2020-07)
Galectins are an endogenous family of β-galactoside-binding proteins that play complex and multifaceted roles at various stages of cancer progression, including modulation of tumor cell proliferation, signaling, adhesion, ...
Galectin-3 drives oligodendrocyte differentiation to control myelin integrity and function
(Nature Publishing Group, 2011-11)
Galectins control critical pathophysiological processes, including the progression and resolution of central nervous system (CNS) inflammation. In spite of considerable progress in dissecting their role within lymphoid ...