info:eu-repo/semantics/article
Galectin-1 suppresses experimental colitis in mice
Fecha
2003-05Registro en:
Santucci, Luca; Fiorucci, Stefano; Rubinstein, Natalia; Mencarelli, Andrea; Pallazzeti, Barbara; et al.; Galectin-1 suppresses experimental colitis in mice; American Gastroenterological Association; Gastroenterology; 124; 5; 5-2003; 1381-1394
0016-5085
CONICET Digital
CONICET
Autor
Santucci, Luca
Fiorucci, Stefano
Rubinstein, Natalia
Mencarelli, Andrea
Pallazzeti, Barbara
Federici, Barbara
Rabinovich, Gabriel Adrián
Morelli, Antonio
Resumen
Uncontrolled T-cell activation plays a critical role in the pathogenesis of inflammatory bowel diseases. Therefore, pharmacologic strategies directed to restore the normal responsiveness of the immune system by deleting inappropriately activated T cells could be efficacious in the treatment of these pathologic conditions. Galectin-1 is an endogenous lectin expressed in lymphoid organs that plays a role in the maintenance of central and peripheral tolerance. The aim of the present study was to evaluate the therapeutic effects of galectin-1 on T-helper cell type 1-mediated experimental colitis induced by intrarectal administration of 2,4,6-trinitrobenzene sulfonic acid (TNBS) in mice.