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PTEN and FOXO3 expression in the prenatal and postnatal human ovary
(Springer/Plenum Publishers, 2020-05)
Purpose: The objective of this study was to analyse the expression and cellular localization of FOXO3, pFOXO3 and PTEN throughout human ovary development both before and after birth. Methods: Foetal, pubertal and adult ...
FoxO3a nuclear localization and its association with beta-catenin and Smads in IFN-alfa-treated hepatocellular carcinoma cell lines
(Mary Ann Liebert Inc, 2014-11)
Interferon-a2b (IFN-a2b) reduces proliferation and increases apoptosis in hepatocellular carcinoma cells by decreasing b-catenin/TCF4/Smads interaction. Forkhead box O-class 3a (FoxO3a) participates in proliferation and ...
Developmental Programming: Prenatal Testosterone Excess on Ovarian SF1/ DAX1/ FOXO3.
(SAGE Publications, 2019-05)
Prenatal testosterone (T) excess, partly via androgenic programming, enhances follicular recruitment/persistence in sheep as in women with polycystic ovariansyndrome (PCOS). Decreased anti-Mullerian hormone (AMH) in early ...
Forkhead box O1 (FOXO1) protein, but not p53, contributes to robust induction of p21 expression in fasted mice
(American Society for Biochemistry and Molecular Biology, 2013-09)
Reporter mice that enable the activity of the endogenous p21 promoter to be dynamically monitored in real time in vivo and under a variety of experimental conditions revealed ubiquitous p21 expression in mouse organs ...
Altered FOXO1 activation in the programming of cardiovascular alterations by maternal diabetes
(Elsevier Ireland, 2019-01)
Maternal diabetes programs cardiovascular alterations in the adult offspring but the mechanisms involved remain unclarified. Here, we addresed whether maternal diabetes programs cardiac alterations related to extracellular ...
Foxo3 gene expression and oxidative status in beta-thalassemia minor subjects
(Associação Brasileira de Hematologia, Hemoterapia e Terapia Celular, 2017-04)
Background Oxidative stress may aggravate symptoms of hemolytic anemias such as beta-thalassemia. FoxO3 activation results in resistance to oxidative stress in fibroblasts and neuronal cell cultures. Objective The purpose ...
Angiotensin II-upregulated MAP kinase phosphatase-3 modulates FOXO1 and p21 in adrenocortical H295R cells
(Cell Press, 2020-03)
MAPK phosphatases (MKP) downregulate the activity of mitogen-activated protein kinases (MAPK), such asERK1/2, and modulate the processes regulated by these kinases. ERK1/2 participate in a wide range of processesincluding ...
Non-canonical mTORC2 Signaling Regulates Brown Adipocyte Lipid Catabolism through SIRT6-FoxO1
(Cell Press, 2019-08)
mTORC2 controls glucose and lipid metabolism, but the mechanisms are unclear. Here, we show that conditionally deleting the essential mTORC2 subunit Rictor in murine brown adipocytes inhibits de novo lipid synthesis, ...
Probiotic Bacillus subtilis Protects against α-Synuclein Aggregation in C. elegans
(Elsevier, 2020-01)
How the gut microbiome affects Parkinson's disease remains unclear. Goya et al. show that the probiotic B. subtilis strain PXN21 inhibits and clears α-synuclein aggregation in a C. elegans model. The bacterium acts via ...
Metformin promotes autophagy in Echinococcus granulosus larval stage
(Elsevier Science, 2018-09)
Cystic echinococcosis is a neglected parasitic disease caused by the larval stage of Echinococcus granulosus for which an effective treatment is not yet available. Since autophagy constitutes a homeostatic mechanism during ...