info:eu-repo/semantics/article
Probiotic Bacillus subtilis Protects against α-Synuclein Aggregation in C. elegans
Fecha
2020-01Registro en:
Goya, María Eugenia; Xue, Feng; Sampedro Torres Quevedo, Cristina; Arnaouteli, Sofia; Riquelme Dominguez, Lourdes; et al.; Probiotic Bacillus subtilis Protects against α-Synuclein Aggregation in C. elegans; Elsevier; Cell Reports; 30; 2; 1-2020; 367-380.e7
2211-1247
2211-1247
CONICET Digital
CONICET
Autor
Goya, María Eugenia
Xue, Feng
Sampedro Torres Quevedo, Cristina
Arnaouteli, Sofia
Riquelme Dominguez, Lourdes
Romanowski, Andrés
Brydon, Jack
Ball, Kathryn L.
Stanley-Wall, Nicola R.
Doitsidou, Maria
Resumen
How the gut microbiome affects Parkinson's disease remains unclear. Goya et al. show that the probiotic B. subtilis strain PXN21 inhibits and clears α-synuclein aggregation in a C. elegans model. The bacterium acts via metabolites and biofilm formation to activate protective pathways in the host, including DAF-16/FOXO and sphingolipid metabolism.