Mostrando ítems 1-10 de 2127
Planejamento experimental aplicado aos estudos de degradação forçada do fármaco Ticagrelor
(Universidade Federal de São CarlosUFSCarPrograma de Pós-Graduação em Química - PPGQCâmpus São Carlos, 2020-08-31)
Stability indicating tests are an essential part during pharmaceutical drug production, besides being a mandatory step for the regulation and approval from the regulatory agencies. Forced degradation consist of an exposure ...
Effect of lubricant degradation on the tribological performance of a wheel-rail system
(2014-09-08)
Abstrac: In this work lubricant degradation and its relationship with tribological behavior was studied. Commercial grease (Sintono Terra HLK) and three versions of a newly developed product (Tribolub) for the Metro system ...
Deconvolução de espectros UV diretamente de soluções de degradação forçada de fármacos
(Universidade Federal de São CarlosUFSCarPrograma de Pós-Graduação em Química - PPGQCâmpus São Carlos, 2022-04-27)
Forced degradation studies (EDFs) are assays which pharmaceuticals are placed under stress conditions, which include acidic, basic, oxidative, high temperature, photodegradation, humidity and metal ions environments. The ...
Degradação forçada dos fármacos nitazoxanida e sofosbuvir e degradação térmica de dispersões sólidas amorfas contendo ritonavir
(Universidade Federal de São CarlosUFSCarPrograma de Pós-Graduação em Química - PPGQCâmpus São Carlos, 2022-04-28)
The first chapter of this work aimed to use design of experiments in the forced degradation of sofosbuvir (SOF) and nitazoxanide (NTZ). The variables pH, temperature and interaction between temperature and H2O2 contributed ...
Degradation modeling for reliability analysis with time-dependent structure based on the inverse gaussian distribution
(Universidade Federal de São CarlosUFSCarPrograma Interinstitucional de Pós-Graduação em Estatística - PIPGEsCâmpus São Carlos, 2017-04-07)
Conventional reliability analysis techniques are focused on the occurrence of failures over
time. However, in certain situations where the occurrence of failures is tiny or almost null, the
estimation of the quantities ...
Investigação e elucidação estrutural por LC-MS/MS e RMN ¹H de impurezas desconhecidas de Ramipril Pellet geradas em estudo de degradação forçada
(Universidade Federal de São CarlosUFSCarPrograma de Pós-Graduação de Mestrado Profissional em Química - PPGQCâmpus São Carlos, 2018-07-27)
The development of a pharmaceutical product comprises multidisciplinary steps, coming from compatibility studies between the active pharmaceutical ingredient (API) and the other raw material (excipients) to studies of ...