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MethylMix 2.0: An R package for identifying DNA methylation genes
(Oxford University Press, 2018-09)
Summary: DNA methylation is an important mechanism regulating gene transcription, and its role in carcinogenesis has been extensively studied. Hyper and hypomethylation of genes is a major mechanism of gene expression ...
Developmental changes and sex differences in DNA methylation and demethylation in hypothalamic regions of the mouse brain
(Landes Bioscience, 2019-08)
DNA methylation is dynamically modulated during postnatal brain development, and plays a key role in neuronal lineage commitment. This epigenetic mark has also recently been implicated in the development of neural sex ...
Cell-free DNA methylation as liquid biopsy for the assessment of fibrosis in patients with nonalcoholic steatohepatitis: a gap between innovation and implementation
(AME Publishing Company, 2017-04)
The presence of cfDNA in the circulating compartment was demonstrated three decades ago , leading to the emergence of liquid biopsy.However, the implementation of cfDNA methylation as a non-invasive molecular tool for the ...
Genome-wide analysis of DNA methylation in human amnion
(HINDAWI publishing Corporation, 2013-02)
The amnion is a specialized tissue in contact with the amniotic fluid, which is in a constantly changing state. To investigate the importance of epigenetic events in this tissue in the physiology and pathophysiology of ...
Differential methylation patterns in apomictic vs. Sexual genotypes of the diplosporous grass Eragrostis curvula
(Multidisciplinary Digital Publishing Institute, 2021-05-10)
DNA methylation is an epigenetic mechanism by which a methyl group is added to a cytosine or an adenine. When located in a gene/regulatory sequence it may repress or de-repress genes, depending on the context and species. ...
Methylation-sensitive Amplified Polymorphism as a Tool to Analyze Wild Potato Hybrids
(Bio-protocol LLC, 2020-07)
Methylation-Sensitive Amplification Polymorphism (MSAP) is a versatile marker foranalyzing DNA methylation patterns in non-model species. The implementation of this technique does not require a reference genome and makes ...
Aberrant DNA methylation of cancer-related genes in giant breast fibroadenoma: A case report
(BioMed Central, 2016)
Introduction. Giant fibroadenoma is an uncommon variant of benign breast lesions. Aberrant methylation of CpG islands in promoter regions is known to be involved in the silencing of genes (for example, tumor-suppressor ...
Mechanisms of DNA damage by photoexcited 9-methyl-β-carbolines
(Royal Society of Chemistry, 2013-06-18)
It has been well documented that β-carboline alkaloids, particularly the 9-methyl derivatives, are efficient photosensitizers. However, structure–activity relationships are missing and the photochemical mechanisms involved ...
Contribution of dysregulated DNA methylation to autoimmunity
(Molecular Diversity Preservation International, 2021-11)
Epigenetic mechanisms, such as DNA methylation, histone modifications, and non-coding RNAs are known regulators of gene expression and genomic stability in cell growth, development, and differentiation. Because epigenetic ...
Methylation of TFAM gene promoter in peripheral white blood cells is associated with insulin resistance in adolescents
(Academic Press Inc Elsevier Science, 2010-05)
Purpose: To explore whether DNA methylation of the mitochondrial transcription factor A (TFAM) promoter is associated with insulin resistance in a sample of adolescents with features of metabolic syndrome. Methods: The ...