info:eu-repo/semantics/article
Contribution of dysregulated DNA methylation to autoimmunity
Fecha
2021-11Registro en:
Funes, Samanta Celeste; Fernández Fierro, Ayleen; Rebolledo Zelada, Diego; Mackern Oberti, Juan Pablo; Kalergis, Alexis M.; Contribution of dysregulated DNA methylation to autoimmunity; Molecular Diversity Preservation International; International Journal of Molecular Sciences; 22; 21; 11-2021; 11892; 1-19
1422-0067
1422-0067
CONICET Digital
CONICET
Autor
Funes, Samanta Celeste
Fernández Fierro, Ayleen
Rebolledo Zelada, Diego
Mackern Oberti, Juan Pablo
Kalergis, Alexis M.
Resumen
Epigenetic mechanisms, such as DNA methylation, histone modifications, and non-coding RNAs are known regulators of gene expression and genomic stability in cell growth, development, and differentiation. Because epigenetic mechanisms can regulate several immune system elements, epigenetic alterations have been found in several autoimmune diseases. The purpose of this review is to discuss the epigenetic modifications, mainly DNA methylation, involved in autoimmune diseases in which T cells play a significant role. For example, Rheumatoid Arthritis and Systemic Lupus Erythematosus display differential gene methylation, mostly hypomethylated 5′-C-phosphate-G-3′ (CpG) sites that may associate with disease activity. However, a clear association between DNA methylation, gene expression, and disease pathogenesis must be demonstrated. A better understanding of the impact of epigenetic modifications on the onset of autoimmunity will contribute to the design of novel therapeutic approaches for these diseases.