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Role of ABCC2 common variants in intrahepatic cholestasis of pregnancy
(W J G Press, 2008-04-07)
The pathogenesis of intrahepatic cholestasis of pregnancy (ICP), a disorder that adversely affects maternal wellbeing and fetal outcome, is unclear. However, multiple factors probably interact along with a genetic ...
Genetic determinants of acquired cholestasis: A systems biology approach
(Frontiers in Bioscience, 2012-01)
Cholestatic liver diseases encompass a complex spectrum of intrahepatic and cholangiocellular cholestasis, whose etiologies include genetic and environmental components. This review focuses on the role of the genetic ...
Is ursodeoxycholic acid detrimental in obstructive cholestasis? A propos of a case of malignant Biliary obstruction
(Mexican Association of Hepatology, 2016-05)
Ursodeoxycholic acid (UDCA) is the first choice medication for most cholestatic hepatopathies, due to its capability to counteract inflammation and bile-acid-induced liver damage, two common features in cholestasis. However, ...
Improved hepatic MRP2/ABCC2 transport activity in LPS-induced cholestasis by aquaporin-1 gene transfer
(Elsevier France-editions Scientifiques Medicales Elsevier, 2019-10)
Multidrug resistance-associated protein 2 (MRP2/ABCC2), a hepatocyte canalicular transporter involved in bile secretion, is downregulated in cholestasis triggered by lipopolysaccharide. The human aquaporin-1 (hAQP1) ...
Adenoviral transfer of human aquaporin-1 gene to rat liver improves bile flow in estrogen-induced cholestasis
(Nature Publishing Group, 2014-08)
Estrogens can cause liver cholestatic disease. As downregulation of hepatocyte canalicular aquaporin-8 (AQP8) water channels has been involved in estrogen-induced bile secretory failure, we tested whether the archetypal ...
Dynamic Localization of Hepatocellular Transporters: Role in Biliary Excretion and Impairment in Cholestasis
(Bentham Science Publishers, 2017-12)
Bile acids, synthesized by hepatocytes from cholesterol, are specific and quantitatively important organic components of bile, where they are the main driving force of the osmotic process that generates bile flow toward ...
A simple microHPLC-UV method for the simultaneous determination of retinol and α-tocopherol in human plasma. Application to intrahepatic cholestasis of pregnancy
(Royal Society of Chemistry, 2014-03)
Objectives: the development of a simple, rapid, sensitive, and accurate HPLC-UV method for the simultaneous determination of retinol and α-tocopherol in human plasma, suitable for the evaluation of these vitamins in pregnant ...
Fetal coenzyme Q10 deficiency in intrahepatic cholestasis of pregnancy
(Elsevier Masson, 2019-08)
Aim: Intrahepatic cholestasis of pregnancy (ICP) is considered a high-risk condition because it may have serious consequences for the fetus health. ICP is characterized by the accumulation of bile acids in maternal serum ...
Coenzyme Q 10 supplementation: A potential therapeutic option for the treatment of intrahepatic cholestasis of pregnancy
(Elsevier Science, 2020-09)
Intrahepatic cholestasis of pregnancy (ICP) is a pregnancy specific liver disease characterized by pruritus, elevated serum bile acids and abnormal liver function that may be associated with severe adverse pregnancy outcomes. ...
Aquaporin gene therapy for cholestasis
(John Wiley & Sons Inc, 2017-01)
This is regarding the editorial “Aquaporin gene therapy for disorders of cholestasis?” by Tradtrantip and Verkman.(1) We thank the authors for their comments in our recent studies.(2,3) Nevertheless, we believe that an ...