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Ketamine Increases the Function of γ-Aminobutyric Acid Type A Receptors in Hippocampal and Cortical Neurons
(Lippincott Williams and Wilkins, 2017)
© 2016, the American Society of Anesthesiologists, Inc. Wolters Kluwer Health, Inc. All Rights Reserved.Background: The dissociative general anesthetic ketamine is a well-known N-methyl-d-aspartate receptor antagonist. ...
TRPM4 activation by chemically- and oxygen deprivation-induced ischemia and reperfusion triggers neuronal death
(Taylor & Francis, 2017)
Cerebral ischemia-reperfusion injury triggers a deleterious process ending in neuronal death. This process has two components, a glutamate-dependent and a glutamate-independent mechanism. In the glutamate-independent ...
Fine-Tuning the TGF beta Signaling Pathway by SARA During Neuronal Development
(Frontiers Media, 2020)
Neural development is a complex process that involves critical events, including cytoskeleton dynamics and selective trafficking of proteins to defined cellular destinations. In this regard, Smad Anchor for Receptor ...
Homeostatic NMDA receptor down-regulation via brain derived neurotrophic factor and nitric oxide-dependent signalling in cortical but not in hippocampal neurons
(WILEY-BLACKWELL, 2011-09)
Nitric oxide (NO) has been proposed to down-regulate NMDA receptors (NMDA-Rs) in a homeostatic manner. However, NMDA-R-dependent NO synthesis also can cause excitotoxic cell death. Using bicuculline-stimulated hippocampal ...
Antioxidant responses of cortex neurons to iron loading
(2006)
Brain cells have a highly active oxidative metabolism, yet they contain only low to moderate superoxide dismutase and catalase activities. Thus, their antioxidant defenses rely mainly on cellular reduced glutathione
levels. ...
Small-molecule aggregation inhibitors reduce excess amyloid in a trisomy 16 mouse cortical cell line
(SOC BIOLGIA CHILE, 2008)
We have previously characterized a number of small molecule organic compounds that prevent the
aggregation of the β-amyloid peptide and its neurotoxicity in hippocampal neuronal cultures. We have now
evaluated the effects ...
Caracterización de un modelo organotípico de cultivos de neuronas corticales de humano derivadas de trauma craneoencefálico.
(2012-11-30)
Introducción: El trauma craneoencefálico (TEC) es un problema de salud global que puede generar en los pacientes que
lo padecen, muerte, discapacidad y/o alteraciones psiquiátricas con gran impacto sobre su desempeño ...
Cdk5 Regulation of the GRAB-Mediated Rab8-Rab11 Cascade in Axon Outgrowth
(Society for Neuroscience, 2017)
Neurons communicate with each other through their axons and dendrites. However, a full characterization of the molecular mechanisms
involved in axon and dendrite formation is still incomplete. Neurite outgrowth requires ...