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Eradication of burst release of copper ions from copper-bearing IUDs by a phytocompound-based electropolymeric coating
(Elsevier Science, 2019-10)
Copper bearing IUDs main disadvantage is the initial high release (burst release) of copper ions that causes an increased inflammatory response in surrounding tissues and several side effects. In this work, we studied the ...
Transcriptional Bursting and Co-bursting Regulation by Steroid Hormone Release Pattern and Transcription Factor Mobility
(Cell Press, 2019-09-19)
Genes are transcribed in a discontinuous pattern referred to as RNA bursting, but the mechanisms regulating this process are unclear. Although many physiological signals, including glucocorticoid hormones, are pulsatile, ...
High-frequency neuronal bursting is essential for circadian and sleep behaviors in drosophila
(Society for Neuroscience, 2021-01)
Circadian rhythms have been extensively studied in Drosophila; however, still little is known about how the electrical properties of clock neurons are specified. We have performed a behavioral genetic screen through the ...
Antibacterial Layer‐by‐Layer Films of Poly(acrylic acid)–Gentamicin Complexes with a Combined Burst and Sustainable Release of Gentamicin
(Wiley-VCH, 2019-09)
There is an urgent need for the development of effective antibacterial coatings to cope with more and more resistant bacterial strains in medical environments, and particularly to prevent nosocomial infections following ...
Development and validation of a mechanistic model for the release of embelin from a polycaprolactone matrix
(Elsevier, 2020-11)
Embelin is a natural agent with antimicrobial, antifungal and analgesic activities. This work presents a mechanistic model for the release of embelin from a polycaprolactone matrix. Based on the results of embelin release ...
The role of emulsion parameters in tramadol sustained-release from electrospun mats
(Elsevier Science, 2019-02)
Tramadol is an analgesic usually prescribed for the management of pain, with a certain risk of addiction in chronic patients. The incorporation of tramadol in sustained-release systems results particularly attractive for ...
Preparation and characterization of lignin microparticles-in-alginate beads for atrazine controlled release
(Springer/Plenum Publishers, 2019-09)
The use of lignin as polymeric matrices for controlled release systems in agriculture is a promising alternative for its revalorization. In this work, different atrazine delivery systems were studied. Lignin derived from ...
Release kinetics of rosemary (Rosmarinus officinalis) polyphenols from polyvinyl alcohol (PVA) electrospun nanofibers in several food simulants
(Elsevier Ltd, 2018-12)
Polyvinyl alcohol (PVA) electrospun mats with antioxidant activity (PVA/Ros) were obtained by incorporating rosemary extract (RE) into the electrospinning precursor solution. RE compounds interact with PVA, favoring the ...
Human serum albumin nanoparticles for ocular delivery of bevacizumab
(Elsevier Science, 2018-04)
Bevacizumab-loaded nanoparticles (B-NP) were prepared by a desolvation process followed by freeze-drying, without any chemical, physical or enzymatic cross-linkage. Compared with typical HSA nanoparticles cross-linked with ...
Intestinal mononuclear cells primed by systemic interleukin-12 display long-term ability to aggravate colitis in mice
(Wiley Blackwell Publishing, Inc, 2016-11)
To address whether the burst of systemic interleukin-12 (IL-12) influences intestinal inflammation elicited by luminal stimuli, we induced IL-12 release by cDNA injection in C57BL/6 mice and simultaneously started dextran ...