β-Lactamase inhibitors have emerged as an effective alternative to reduce the effects of resistance against β-lactam antibiotics. The Streptomyces genus is known for being an exceptional natural source of antimicrobials ...

Early after the introduction of the first (narrow spectrum) penicillins into clinical use, penicillinase-producing staphylococci replaced (worldwide) the previously susceptible microorganisms. Similarly, the extensive use ...

The diazabicyclooctane (DBO) avibactam (AVI) reversibly inactivates most serine-lactamases. Previous investigations showed that inhibition constants of AVI toward class A PER-2 are reminiscent of values observed for class ...

Bacterial resistance refers to bacteria capacity to evade antibiotic action, which constitutes a public health issue. This resistance is given by β-lactamase enzymes that break the drug rings and alter its function. To ...

β-Lactamases are responsible for the hydrolysis of the β-lactam ring on many known antibiotics, thus conferring resistance to bacteria. The increase in the number of β-lactamases and other resistance mechanisms, together ...

β-lactamases are a primary cause of bacterial resistance to β-lactam antibiotics for many important human pathogens (particularly Gram-negative bacteria) (Hermann, Pradon, Harvey, & Mulholland, 2009). Inhibitors of ...

important human pathogens (particularly Gram-negative bacteria) [1]. Inhibitors of β-lactamase have been implemented as a dual therapy with antibiotics, but there are only four inhibitors clinically approved and resistance ...