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Production of β-lactamase inhibitors by Streptomyces species
(2018-09-01)
β-Lactamase inhibitors have emerged as an effective alternative to reduce the effects of resistance against β-lactam antibiotics. The Streptomyces genus is known for being an exceptional natural source of antimicrobials ...
β -lactamase-mediated Resistance: A Biochemical, Epidemiological and Genetic Overview
(Bentham Science Publ Ltd, 2013-01)
Early after the introduction of the first (narrow spectrum) penicillins into clinical use, penicillinase-producing staphylococci replaced (worldwide) the previously susceptible microorganisms. Similarly, the extensive use ...
Structural insights into the inhibition of the extended-spectrum -lactamase PER-2 by avibactam
(American Society for Microbiology, 2019-08)
The diazabicyclooctane (DBO) avibactam (AVI) reversibly inactivates most serine-lactamases. Previous investigations showed that inhibition constants of AVI toward class A PER-2 are reminiscent of values observed for class ...
In silico mutations of TEM-1 β-lactamase show changes in structure and drug-enzyme affinity binding by molecular docking
(2016)
Bacterial resistance refers to bacteria capacity to evade antibiotic action, which constitutes a public
health issue. This resistance is given by β-lactamase enzymes that break the drug rings and alter its function. To ...
Studying the Binding Affinity Determinants of a Derivative Series from Sulbactam and Clavulanate as β-Lactamase Inhibitors
(2015)
β-Lactamases are responsible for the hydrolysis of the β-lactam ring on many known antibiotics, thus
conferring resistance to bacteria. The increase in the number of β-lactamases and other resistance
mechanisms, together ...
The urgent need for metallo-β-lactamase inhibitors: an unattended global threat
(Elsevier Ltd, 2022)
Use of β-lactam/β-lactamase inhibitors for extended-spectrum-β-lactamase infections: defining the right patient population
(American Society for MicrobiologyAntimicrobial agents and chemotherapy, 2017)
Understanding the Covalent binding of Clavulanate against beta-lactamases (TEM-1 and KPC-2) with QM/ MM methods.
(2017)
β-lactamases are a primary cause of bacterial resistance to β-lactam antibiotics for many important human pathogens
(particularly Gram-negative bacteria) (Hermann, Pradon, Harvey, & Mulholland, 2009). Inhibitors of ...
Understanding the covalent inhibition of Clavulanate against beta-lactamases (TEM-1 and KPC-2) with QM/MM screening methods
(2017)
important human pathogens (particularly Gram-negative bacteria) [1]. Inhibitors of β-lactamase
have been implemented as a dual therapy with antibiotics, but there are only four inhibitors
clinically approved and resistance ...