Ponencia
Understanding the covalent inhibition of Clavulanate against beta-lactamases (TEM-1 and KPC-2) with QM/MM screening methods
Fecha
2017Institución
Resumen
important human pathogens (particularly Gram-negative bacteria) [1]. Inhibitors of β-lactamase
have been implemented as a dual therapy with antibiotics, but there are only four inhibitors
clinically approved and resistance to these compounds is also risin