Studying the Binding Affinity Determinants of a Derivative Series from Sulbactam and Clavulanate as β-Lactamase Inhibitors

Abstract

β-Lactamases are responsible for the hydrolysis of the β-lactam ring on many known antibiotics, thus conferring resistance to bacteria. The increase in the number of β-lactamases and other resistance mechanisms, together with the few new antibiotics disco