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Antibody-induced crosslinking and cholesterol-sensitive, anomalous diffusion of nicotinic acetylcholine receptors
(Wiley Blackwell Publishing, Inc, 2020-03)
Synaptic strength depends on the number of cell-surface neurotransmitter receptors in dynamic equilibrium with intracellular pools. Dysregulation of this homeostatic balance occurs, for example in myasthenia gravis, an ...
Molecular and Physicochemical Aspects of Local Anesthetics Acting on Nicotinic Acetylcholine Receptor-containing Membranes
(Bentham Science Publishers, 2002-04)
Local anesthetics inhibit the ion channel activity of nicotinic acetylcholine receptors in a noncompetitive fashion. This inhibitory action is ascribed to two possible inhibitory mechanisms: an open-channel-blocking mechanism ...
Neuronal nicotinic acetylcholine receptor-cholesterol crosstalk in Alzheimer's disease
(Elsevier Science, 2010-05-03)
Alzheimer’s disease (AD) is one of the most devastating diseases of the central nervous system (CNS). It is characterized by two neuropathological findings: amyloid plaques and neurofibrillary tangles. AD is also accompanied ...
Critical role of hippocampal muscarinic acetylcholine receptors on memory reconsolidation in mice
(Academic Press Inc Elsevier Science, 2021-01)
Over the years, experimental and clinical evidence has given support to the idea that acetylcholine (Ach) plays an essential role in mnemonic phenomena. On the other hand, the Hippocampus is already known to have a key ...
Commentary: Nicotinic acetylcholine receptor α9 and α10 subunits are expressed in the brain of mice
(Frontiers Media S.A., 2018-05)
Nicotinic receptor M3 transmembrane domain: Position 8′ contributes to channel gating
(American Society for Pharmacology and Experimental Therapeutics, 2002-08-01)
The nicotinic acetylcholine receptor (nAChR) is a pentamer of homologous subunits with composition α2βεδ in adult muscle. Each subunit contains four transmembrane domains (M1-M4). Position 8′ of the M3 domain is phenylalanine ...
The noncompetitive inhibitor quinacrine modifies the desensitization kinetics of muscle acetylcholine receptors
(American Society for Pharmacology and Experimental Therapeutics, 2001-08)
Quinacrine has been shown to act as a noncompetitive inhibitor of the nicotinic acetylcholine receptor (nAChR). However, its mechanism of action is still a matter of controversy. We analyzed in detail the action of quinacrine ...
Effect of acetylcholine, pilocarpine, serotonin and adrenaline on the in vitro gastric motility of Hoplias malabaricus (Teleostei)Effect of acetylcholine, pilocarpine, serotonin and adrenaline on the in vitro gastric motility of Hoplias malabaricus (Teleostei)
(Universidade Federal de Santa Maria, 1997)
Functional and structural interaction of (-)-Reboxetine with the human α4β2 nicotinic acetylcholine receptor
(American Society for Pharmacology and Experimental Therapeutics, 2013-01)
The interaction of the selective norepinephrine reuptake inhibitor (-)-reboxetine with the human α4β2 nicotinic acetylcholine receptor (nAChR) in different conformational states was studied by several functional and ...
Characterization of the dizocilpine binding site on the nicotinic acetylcholine receptor
(American Society for Pharmacology and Experimental Therapeutics, 2001-05)
Although the dissociative anesthetic dizocilpine [(+)-MK-801] inhibits nicotinic acetylcholine receptor (AChR) function in a noncompetitive manner, the location of the dizocilpine binding site(s) has yet to be clearly ...