info:eu-repo/semantics/article
Molecular and Physicochemical Aspects of Local Anesthetics Acting on Nicotinic Acetylcholine Receptor-containing Membranes
Fecha
2002-04Registro en:
Arias, Hugo Rubén; Blanton, Michael P.; Molecular and Physicochemical Aspects of Local Anesthetics Acting on Nicotinic Acetylcholine Receptor-containing Membranes; Bentham Science Publishers; Mini-reviews In Medicinal Chemistry; 2; 4; 4-2002; 385-410
1389-5575
CONICET Digital
CONICET
Autor
Arias, Hugo Rubén
Blanton, Michael P.
Resumen
Local anesthetics inhibit the ion channel activity of nicotinic acetylcholine receptors in a noncompetitive fashion. This inhibitory action is ascribed to two possible inhibitory mechanisms: an open-channel-blocking mechanism and/or an allosteric process where the drug binds either to the closed channel or to other nonluminal sites, respectively.