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Studies on quinones. Part 38: Synthesis and leishmanicidal activity of sesquiterpene 1,4-quinones
(PERGAMON-ELSEVIER SCIENCE LTD, 2003-11-03)
The reaction of (+)-euryfuran 1 with several benzo-, naphtho- and benzo[b]thiophene-1,4-quinones in acetic acid yields the corresponding euryfuryl-1.4-quinones 3, 5, 7, 8, 10, 12, and 14. The structure of compounds 7, 8, ...
ESR, electrochemical and ORAC studies of nitro compounds with potential antiprotozoal activity
(2010)
Cyclic Voltammetry (CV) and electron spin resonance (ESR) techniques were used in the investigation of several potentially antiprotozoal nitro derivatives of dihydroquinoxaline and indazole. A self-protonation process ...
The Paraguayan Rhinella toad venom: Implications in the traditional medicine and proliferation of breast cancer cells
(Elsevier Ireland Ltd, 2017)
© 2017 Elsevier Ireland Ltd Ethnopharmacological relevance Toads belonging to genus Rhinella are used in Paraguayan traditional medicine to treat cancer and skin infections. Aim of the study The objective of the study was ...
ESR and electrochemical study of 5-nitroindazole derivatives with antiprotozoal activity
(PERGAMON-ELSEVIER SCIENCE LTD, 2006-01)
The electrochemistry of 3-alkoxy- and 3-hydroxy-1-[(omega-(dialkylamino)alkyl]-5-nitroindazole derivatives were characterized using cyclic voltammetry in DMSO. The nitro reduction process was studied and this was affected ...
Indazole N-oxide derivatives as antiprotozoal agents: Synthesis, biological evaluation and mechanism of action studies
(PERGAMON-ELSEVIER SCIENCE LTD, 2006-05-15)
A series of indazole N-oxide derivatives have been synthesized and their antichagasic and leishmanocidal properties studied. 3-Cyano-2-(4-iodophenyl)-2H-indazole N-1-oxide exhibited interesting antichagasic activity on the ...
Chemical profiling, antioxidant, anticholinesterase, and antiprotozoal potentials of artemisia copa phil. (Asteraceae)
(Frontiers Media, 2020)
Artemisia copa Phil. (Asteraceae) (known as copa-copa) is a native species of Chile used as an infusion in traditional medicine by Atacamenos people in the Altiplano, highlands of northern Chile. In this research, we have ...
Pentamidine exerts in vitro and in vivo anti Trypanosoma cruzi activity and inhibits the polyamine transport in Trypanosoma cruzi
(Elsevier, 2014)
Pentamidine is an antiprotozoal and fungicide drug used in the treatment of leishmaniasis and African trypanosomiasis. Despite its extensive use as antiparasitic drug, little evidence exists about the effect of pentamidine ...
ESR spin trapping studies of free radicals generated from nitrofuran derivative analogues of nifurtimox by electrochemical and Trypanosoma cruzi reduction
(TAYLOR & FRANCIS LTD, 2003-08)
Electron spin resonance (ESR) spectra of radicals obtained from two analogues of the antiprotozoal drug nifurtimox by electrolytic and Trypanosoma cruzi reduction were analyzed. The electrochemistry of these compounds was ...
In vitro and in vivo antitrypanosomatid activity of 5-nitroindazoles
(2009)
Previously, we have identified a series of 5-nitroindazoles with good antiprotozoal activities, against Trypanosoma cruzi epimastigotes and Trichomonas vaginalis. Most of them have shown very low unspecific toxicity on ...