Artículo de revista
Studies on quinones. Part 38: Synthesis and leishmanicidal activity of sesquiterpene 1,4-quinones
Fecha
2003-11-03Registro en:
BIOORGANIC & MEDICINAL CHEMISTRY 11 (22): 4713-4718 NOV 3 2003
0968-0896
Autor
Valderrama, Jaime A.
Benites, Julio
Cortés, Manuel
Pessoa Mahana, Hernán
Prina, Eric
Fournet, Alain
Institución
Resumen
The reaction of (+)-euryfuran 1 with several benzo-, naphtho- and benzo[b]thiophene-1,4-quinones in acetic acid yields the corresponding euryfuryl-1.4-quinones 3, 5, 7, 8, 10, 12, and 14. The structure of compounds 7, 8, 12, and 14 was assigned through 2D NMR H-1-C-13 HMBC experiments. The influence of the acidity of the solvent upon the reactivity and regioselectivity of the quinones to the oxidative coupling reaction, is discussed. The in vitro activity of the euryfurylquinones and their corresponding precursors against Leishmania amazonensis is described.