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Ruthenium(II)-mercapto Complexes with Anticancer Activity Interact with Topoisomerase IB
(2020-03-01)
Herein we present four new ruthenium(II) complexes: [Ru(mtz)2(dppb)] (1), [Ru(mmi)2(dppb)] (2), [Ru(dmp)2(dppb)] (3), and [Ru(mpca)2(dppb)] (4), where mtz = 2-mercaptothiazoline; mmi = 2-mercapto-1-methyl-imidazole; dmp = ...
Estudo computacional da interação de compostos naftoquinônicos e a enzima DNA topoisomerase IB humana por modelagem comparativa, docking e dinâmica molecular
(Instituto Oswaldo Cruz, 2012)
As DNA topoisomerases constituem um família de enzimas que
desempenham um importante papel nos processos de replicação e atuam na
regulação da topologia do DNA, inserindo uma quebra temporária em uma ou em
ambas as fitas ...
Further constituents of Galianthe thalictroides (Rubiaceae) and inhibition of DNA topoisomerases I and II alpha by its cytotoxic beta-carboline alkaloids
(Pergamon-elsevier Science LtdOxfordInglaterra, 2014)
Identification of Anziaic Acid, a Lichen Depside from Hypotrachyna sp., as a New Topoisomerase Poison Inhibitor
(2013)
Topoisomerase inhibitors are effective for antibacterial and anticancer therapy because they can lead to the accumulation of the intermediate DNA cleavage complex formed by the topoisomerase enzymes, which trigger cell ...
Studies on quinones. Part 43: Synthesis and cytotoxic evaluation of polyoxyethylene-containing 1,4-naphthoquinones
(PERGAMON-ELSEVIER SCIENCE LTD, 2008)
A series of naphthoquinones 2,3-disubstituted with chlorine and oxyethylene groups have been prepared from 2,3-dichloro- and 2,3-dimethoxy-1,4-naphthoquinone. The members of these series were tested on normal human. broblasts ...
Cytotoxic Activity, Topoisomerase I Inhibition and In Silico Studies of New Sesquiterpene-aryl Ester Derivatives of (-) Drimenol
(MDPI, 2023-05)
In this study, we aimed to evaluate two sets of sesquiterpene-aryl derivatives linked by an ester bond, their cytotoxic activities, and their capacity to activate caspases 3/7 and inhibit human topoisomerase I (TOP1). A ...
Síntese e caracterização de Complexos de Pd(II) com potencial atividade citotóxica e inibidores das enzimas Topoisomerase II
(Universidade Federal de São CarlosUFSCarPrograma de Pós-Graduação em Química - PPGQCâmpus São Carlos, 2018-05-29)
It is known that cancer is a set of more than 100 diseases which are the second largest cause of death in the world. There are several factors related to the growth of tumors, showing different pathway for the planning of ...