artículo
Studies on quinones. Part 43: Synthesis and cytotoxic evaluation of polyoxyethylene-containing 1,4-naphthoquinones
Fecha
2008Registro en:
10.1016/j.bmc.2008.02.018
1464-3391
0968-0896
MEDLINE:18299197
WOS:000255245900022
Autor
Valderrama, Jaime A.
Leiva, Hilda
Rodriguez, Jaime A.
Theoduloz, Cristina
Schmeda Hirshmann, Guillermo
Institución
Resumen
A series of naphthoquinones 2,3-disubstituted with chlorine and oxyethylene groups have been prepared from 2,3-dichloro- and 2,3-dimethoxy-1,4-naphthoquinone. The members of these series were tested on normal human. broblasts and on a panel of four human cancer cell lines. Antitumor activities, which were in the range of IC50 1.3-89.5 mu M, discussed in terms of LUMO energy, lipophilicity and size of the polyoxyethylene moiety. (C) 2008 Elsevier Ltd. All rights reserved.