Artículos de revistas
Further constituents of Galianthe thalictroides (Rubiaceae) and inhibition of DNA topoisomerases I and II alpha by its cytotoxic beta-carboline alkaloids
Registro en:
Bioorganic & Medicinal Chemistry Letters. Pergamon-elsevier Science Ltd, v. 24, n. 5, n. 1358, n. 1361, 2014.
0960-894X
1464-3405
WOS:000331705200022
10.1016/j.bmcl.2014.01.039
Autor
Figueiredo, PD
Perdomo, RT
Garcez, FR
Matos, MDC
de Carvalho, JE
Garcez, WS
Institución
Resumen
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) A new cytotoxic beta-carboline alkaloid, 1-methyl-3-(2-hydroxypropan-2-yl)-2-(5-methoxy-9H-beta-carbolin-1-yl)-cyclopentanol (1), was isolated from roots of Galianthe thalictroides, together with the alkaloid 1-(hydroxymethyl)-3-(2-hydroxypropan-2-yl)-2-(5-methoxy-9H-beta-carbolin-1-yl)-cyclopentanol (2), the anthraquinones 1-methyl-alizarin and morindaparvin-A, the coumarin scopoletin, homovanillic alcohol, (-)-epicatechin, and the steroids stigmast-4-en-3-one, 4,22-stigmastadien-3-one, campest-4-en-3-one, stigmast-4-en-3,6-dione, 6-beta-hydroxy-stigmast-4-en-3-one, stigmasterol, campesterol, beta-sitosterol, and beta-sitosterol-3-O-beta-D-glucopyranoside. Among the previously known compounds, homovanillic alcohol is a novel finding in Rubiaceae, while 1-methyl-alizarin, morindaparvin-A, scopoletin, stigmast-4-en-3-one, 4,22-stigmastadien-3-one, campest-4-en-3-one, stigmast-4-en-3,6-dione, and 6-beta-hydroxy-stigmast-4-en-3-one is reported for the first time in the genus Galianthe. The cytotoxic beta-carboline alkaloids 1 and 2 exhibited potent antitopoisomerase I and IIa activities and strong evidence is provided for their action as topoisomerase IIa poisons and redox-independent inhibitors. (C) 2014 Elsevier Ltd. All rights reserved. 24 5 1358 1361 Fundect-MS CPq-PROPP-UFMS Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)