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Early Detection of Pancreatic Intraepithelial Neoplasias (PanINs) in Transgenic Mouse Model by Hyperpolarized 13C Metabolic Magnetic Resonance Spectroscopy
(Molecular Diversity Preservation International, 2020-05-25)
While pancreatic cancer (PC) survival rates have recently shown modest improvement, the disease remains largely incurable. Early detection of pancreatic cancer may result in improved outcomes and therefore, methods for ...
The complex interactions between obesity, metabolism and the brain
(Frontiers Media S.A., 2019-05-24)
Obesity is increasing at unprecedented levels globally, and the overall impact ofobesity on the various organ systems of the body is only beginning to be fullyappreciated. Because of the myriad of direct and indirect effects ...
Adaptations in energy metabolism and gene family expansions revealed by comparative transcriptomics of three Chagas disease triatomine vectors
(BioMed Central, 2018-04)
Background: Chagas disease is a parasitic infection caused by Trypanosoma cruzi. It is an important public health problem affecting around seven to eight million people in the Americas. A large number of hematophagous ...
Metabolic plasticity of activated immune cells: advantages for suppression of covid-19 disease by melatonin
(Bangkok Editors, 2020-06)
COVID-19 has infected hundreds of thousands and killed tens of thousands of people worldwide and it continues to ravage societies as well as the fiscal and economic stability of several countries. Currently, several drugs ...
Alterations in cell adhesion molecules and other biomarkers of cardiovascular disease in patients with metabolic syndrome
(Elsevier Ireland, 2008-12)
Metabolic syndrome is considered a hyperinsulinemic and inflammatory state closely associated to endothelial dysfunction causing an increased incidence of ischemic cardiovascular events and high mortality. The main objective ...
Glucose metabolism regulates T cell activation, differentiation, and functions
(Frontiers Research Foundation, 2015-01)
The adaptive immune system is equipped to eliminate both tumors and pathogenic microorganisms. It requires a series of complex and coordinated signals to drive the activation, proliferation, and differentiation of appropriate ...
Modifications in nitric oxide and superoxide anion metabolism induced by fructose overload in rat heart are prevented by (−)-epicatechin
(Royal Society of Chemistry, 2016-04)
Fructose overload promotes functional and metabolic derangements in humans and in animal experimental models. Evidence suggests that dietary flavonoids have the ability to prevent/attenuate the development of metabolic ...