info:eu-repo/semantics/lecture
Regulation of glucose metabolism in neurons by Wnt3a and adiponectin, a possible molecular link between Alzheimer´s disease and obesity
Autor
Cisternas, Pedro
Inestrosa-Cantin, Nibaldo Manuel
Institución
Resumen
The brain is the organ with the highest rate of glucose consumption. In several disorders including Alzheimer´s disease (AD) and obesity there is a decrease in the brain capacity
to utilize glucose. It has been suggested that obesity increases the risk of AD. However, the cellular mechanisms to explain this correlation have not been described. The cross talk
between the adipose tissue and the brain could be mediated via the elaboration of endocrine agents, collectively termed adipokines. Some of these adipokines including adiponectin
(downregulated in obesity) impact directly the metabolism of glucose. FONDECYT FONDECYT