Buscar
Mostrando ítems 41-50 de 149
Galectins
(Cold Spring Harbor Laboratory Press, 2022)
Galectins are among the most widely expressed class of lectins in all organisms. They typically bind β-galactose-containing glycoconjugates and share primary structural homology in their carbohydrate-recognition domains ...
Galectin-3 Exerts a Pro-differentiating and Pro-myelinating Effect Within a Temporal Window Spanning Precursors and Pre-oligodendrocytes: Insights into the Mechanisms of Action
(Humana Press, 2019-10)
Oligodendrocytes (OLG) are the cells resident in the CNS responsible for myelination. OLG undergo a succession of morphological and molecular changes along several maturational stages. Galectin-3 (Gal-3) is a 25- to 35-KDa ...
Galectin-3-mediated glial crosstalk drives oligodendrocyte differentiation and (Re)myelination
(Frontiers Media S.A., 2018-09)
Galectin-3 (Gal-3) is the only chimeric protein in the galectin family. Gal-3 structure comprises unusual tandem repeats of proline and glycine-rich short stretches bound to a carbohydrate-recognition domain (CRD). The ...
DTU i isolates of Trypanosoma cruzi induce upregulation of Galectin-3 in murine myocarditis and fibrosis
(Cambridge University Press, 2014-01)
Chagas heart disease is a major public concern since 30% of infected patients develop cardiac alterations. The relationship between Trypanosoma cruzi discrete typing units (DTUs) and the biological properties exhibited by ...
Characterization of a neutralizing anti-human galectin-1 monoclonal antibody with angioregulatory and immunomodulatory activities
(Springer, 2021-10)
Galectins, a family of highly conserved β-galactoside-binding proteins, control tumor progression by modulating different hallmarks of cancer. Galectin-1 (Gal-1), a proto-type member of this family, plays essential roles ...
Galectins: Multitask signaling molecules linking fibroblast, endothelial and immune cell programs in the tumor microenvironment
(Academic Press Inc Elsevier Science, 2018-11)
Tumor cells corrupt surrounding normal cells instructing them to support proliferative, pro-angiogenic and immunosuppressive networks that favor tumorigenesis and metastasis. This dynamic cross-talk is sustained by a range ...
Galectin-8: a matricellular lectin with key roles in angiogenesis
(Oxford University Press, 2014-10)
Galectin-8 (gal-8) is a “tandem-repeat”-type galectin, containing two carbohydrate recognition domains connected by a linker peptide. gal-8 is expressed both in the cytoplasm and nucleus in vascular endothelial cells (ECs) ...
Tolerance signaling molecules and pregnancy: IDO, galectins, and the renaissance of regulatory T cells
(Blackwell Munksgaard, 2007)
Altered expression of galectin-3 induces cortical thymocyte depletion and premature exit of immature thymocytes during Trypanosoma cruzi infection
(Amer Soc Investigative Pathology, Inc, 2007)
During acute infection with Trypanosoma cruzi, the causative agent of Chagas´ disease, the thymus undergoes intense atrophy followed by a premature escape of CD4+CD8+ immature cortical thymocytes. Here we report a pivotal ...
Extracellular Galectin-3 Induces Accelerated Oligodendroglial Differentiation Through Changes in Signaling Pathways and Cytoskeleton Dynamics
(Humana Press, 2019-01)
Galectin-3 (Gal-3) is a chimeric protein structurally composed of unusual tandem repeats of proline and short glycine-rich segments fused onto a carbohydrate recognition domain. Our studies have previously demonstrated ...