info:eu-repo/semantics/article
Tolerance signaling molecules and pregnancy: IDO, galectins, and the renaissance of regulatory T cells
Registro en:
Terness, Peter; Kallikourdes, Marinos; Betz, Alexander G.; Rabinovich, Gabriel Adrián; Saito, Shigeru; et al.; Tolerance signaling molecules and pregnancy: IDO, galectins, and the renaissance of regulatory T cells; Blackwell Munksgaard; American Journal of Reproductive Immunology; 58; 3; -1-2007; 238-254
1046-7408
1600-0897
CONICET Digital
CONICET
Autor
Terness, Peter
Kallikourdes, Marinos
Betz, Alexander G.
Rabinovich, Gabriel Adrián
Saito, Shigeru
Clarck, David A.
Resumen
Is the concept of maternal tolerance preventing rejection of the semi-allogeneic 'fetal allograft' still valid?. Compilation of expert reviews of literature and recent advances in research on indoleamine-2,3 dioxygenase (IDO), regulatory T cells and galectin-1. A role for IDO in pregnancy success remains speculative, but solid data exist to support a role for Treg cells, and for galectin-1 in induction and action of Treg cells. Just as several signals may need to be simultaneously present to induce Th1 cytokine-triggered abortions, more than 1 signal may need to be simultaneously present to prevent rejection and ensure success. Both complement and coagulation pathways appear necessary for embryo execution. Fil: Terness, Peter. Universität Heidelberg; Albania Fil: Kallikourdes, Marinos. MRC Laboratory of Molecular Biology; Reino Unido Fil: Betz, Alexander G.. MRC Laboratory of Molecular Biology; Reino Unido Fil: Rabinovich, Gabriel Adrián. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina Fil: Saito, Shigeru. Universidad de Toyama; Japón Fil: Clarck, David A.. Mc Master University; Canadá