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Differential antigenotoxic and cytoprotective effect of amifostine in idarubicin-treated mice
(Wiley-liss, Inc, 2002-12)
In this study we evaluated the antigenotoxic and cytoprotective capabilities of WR-2721 [S-2-(3aminopropylamino)-ethylphosphorothioic acid (amifostine)] in different normal tissues of BALB/c mice treated with idarubicin ...
New insights in the DNA-[Cr(phen)2(dppz)]3+ binding and photocleavage properties by the complex with an intercalating ligand
(Elsevier Science Inc, 2010-07)
Due to the key role of DNA in cell life and pathological processes, the design of specific chemical nucleases, fic chemical nucleases, DNA probes and alkylating agents is an important research area for the development of ...
DNA Oxidation Photoinduced by Norharmane Rhenium(I) Polypyridyl Complexes: Effect of the Bidentate N,N′-Ligands on the Damage Profile
(Wiley VCH Verlag, 2018-09)
ReI-polypyridyl complexes have interesting and distinctive photochemical and photosensitizing properties. This work describes the capability to induce (or photoinduce) DNA damage of three ReI-complexes with a naturally ...
Resveratrol induces H3 and H4K16 deacetylation and H2A.X phosphorylation in Toxoplasma gondii
(BioMed Central, 2021-12)
Objective: Resveratrol (RSV) is a multitarget drug that has demonstrated activity against Toxoplasma gondii in macrophage and human foreskin fbroblast (HFF) cell line infection models. However, the mechanism of action of ...
Compromised nuclear envelope integrity drives TREX1-dependent DNA damage and tumor cell invasion
(Cell Press, 2021-09-21)
Although mutations leading to a compromised nuclear envelope cause diseases such as muscular dystrophies or accelerated aging, the consequences of mechanically induced nuclear envelope ruptures are less known. Here, we ...
Imidacloprid Causes DNA Damage in Fish: Clastogenesis as a Mechanism of Genotoxicity
(Springer, 2018-04)
Neonicotinoids are one of the most widely used insecticides in the world. DNA damage is considered an early biological effect which could lead to reproductive and carcinogenic effects. The present study aimed to evaluate ...
Chronic exposure to low-dose of X-rays induces DNA double-strand breaks in mammalian cells
(Inderscience Enterprises, 2011-10)
The purpose of present study is to evaluate the induction of clastogenic effect after chronic exposure to low dose of ionising radiation in both CHO-K1 cells and in their DNA Double-Strand Breaks (DSBs)-repair deficient ...
Mechanisms of DNA damage by photoexcited 9-methyl-β-carbolines
(Royal Society of Chemistry, 2013-06-18)
It has been well documented that β-carboline alkaloids, particularly the 9-methyl derivatives, are efficient photosensitizers. However, structure–activity relationships are missing and the photochemical mechanisms involved ...
TcPARP: A DNA damage-dependent poly(ADP-ribose) polymerase from Trypanosoma cruzi
(Elsevier, 2008-03)
Poly(ADP-ribose) polymerase (PARP) is a nuclear enzyme present in most eukaryotes and has been involved in processes such as DNA repair and gene expression. The poly(ADP-ribose) polymer (PAR) is mainly catabolised by ...