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Two recombinant human interferon-beta 1a pharmaceutical preparations produce a similar transcriptional response determined using whole genome microarray analysis
(Dustri-Verlag Dr. Karl Feistle, 2008-02)
Objectives: Recombinant human interferon-beta (IFN-b) is a well-established treatment for multiple sclerosis (MS). The regulatory process for marketing authorization of biosimilars is currently under debate in certain ...
A comprehensive approach toward concomitant triclabendazole polymorphism in pharmaceutical products
(Elsevier, 2021-04)
Triclabendazole (TCB) is a highly effective and low-cost anti-parasitic active pharmaceutical ingredient (API) used in the treatment of fascioliasis, a neglected tropical disease caused by Fasciola hepatica. It belongs to ...
Flow-batch technique for the simultaneous enzymatic determination of levodopa and carbidopa in pharmaceuticals using PLS and successive projections algorithm
(Elsevier Science, 2008-05)
An enzymatic flow-batch system with spectrophotometric detection was developed for simultaneous determination of levodopa [(S)-2 amino-3-(3,4-dihydroxyphenyl)propionic acid] and carbidopa [(S)-3-(3,4-dihydroxyphenyl)-2-h ...
Enzyme-catalyzed preparation of novel fatty acid derivatives of pyridoxine with surfactant activity
(Taylor & Francis Ltd, 2002-12)
A series of novel fatty acid derivatives of pyridoxine, one of the three members of the vitamin B6 group, has been prepared. These products were obtained using an enzymatic approach. Several lipases catalyzed esterification ...
Lipase-catalyzed regioselective preparation of fatty acid esters of hydrocortisone
(Elsevier Science Inc, 2009-11)
A series of fatty acid derivatives of hydrocortisone has been prepared by an enzymatic methodology. Nine 21-monoacyl products and one 3,11,17-triacetyl derivative, nine of them novel compounds, were obtained in a highly ...
Os desafios da indústria farmacêutica global e o redesenho do negócio pela MerckOs desafios da indústria farmacêutica global e o redesenho do negócio pela Merck
(RAE - Revista de Administracao de EmpresasRAE - Revista de Administração de EmpresasRAE-Revista de Administração de Empresas, 2001)
Evaluation of microcrystalline cellulose II (MCCII) as an alternative extrusion-spheronization aid
(Govi-Verlag Pharmazautischer VerlagDiseño y Formulación de Medicamentos Cosméticos y AfinesBerlín, Alemania, 2023)
Preparation of Chloramphenicol/Amino Acid Combinations Exhibiting Enhanced Dissolution Rates and Reduced Drug-Induced Oxidative Stress
(Springer, 2017-11-20)
Chloramphenicol is an old antibiotic agent that is re-emerging as a valuable alternative for the treatment of multidrug-resistant pathogens. However, it exhibits suboptimal biopharmaceutical properties and toxicity profiles. ...
Effect of temperature on the chromatographic retention of ionizable compounds. III. Modeling retention of Pharmaceuticals as a function of eluent pH and column temperature in RPLC
(Wiley VCH Verlag, 2008-04)
We propose a general simple equation for accurately predicting the retention factors of ionizable compounds upon simultaneous changes in mobile phase pH and column temperature at a given hydroorganic solvent composition. ...
Binary and ternary complexes of norfloxacin to improve the solubility of the active pharmaceutical ingredient
(Future Medicine Ltd., 2018-09)
Binary and ternary complexes with hydroxypropyl-β-cyclodextrin (HPβCD), using glutamic acid (GA), proline (PRO) or lysine (LIS) as the third component, where developed to increase the solubility and the dissolution rate ...