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AtCAF-1 mutants show different DNA damage responses after ultraviolet-B than those activated by other genotoxic agents in leaves
(Wiley Blackwell Publishing, Inc, 2019-06)
Chromatin assembly factor-1 (CAF-1) is a histone H3/H4 chaperone that participates in DNA and chromatin interaction processes. In this manuscript, we show that organs from CAF-1 deficient plants respond differently to ...
Participation of heat shock proteins in DNA repair mechanisms in cancer
(Nova Science Publishers, 2010)
Heat shock proteins (HSPs) are well known as molecular chaperones, playing important roles in cellular metabolism, escorting other proteins during aggregation, disaggregation, folding, and unfolding. They have been classified ...
The identification of translesion DNA synthesis regulators: inhibitors in the spotlight
(Elsevier, 2015-08)
Over the past half-century, we have become increasingly aware of the ubiquity ofDNA damage. Under the constant exposure to exogenous and endogenous genomic stress, cells must attempt to replicate damaged DNA. The encounter ...
CDK5-mediated phosphorylation of p19INK4d avoids DNA damage-induced neurodegeneration in mouse hippocampus and prevents loss of cognitive functions
(Elsevier, 2014-04)
DNA damage, which perturbs genomic stability, has been linked to cognitive decline in the aging human brain, and mutations in DNA repair genes have neurological implications. Several studies have suggested that DNA damage ...
Evaluation of DNA Damage of Mare Granulosa Cells Before and After Cryopreservation Using a Chromatin Dispersion Test
(Elsevier Science Inc, 2019-01)
DNA fragmentation of granulosa cells might be related to developmental competence of the equine oocyte. Granulosa cells are commonly stored before DNA fragmentation assessment, but the effect of preservation methods on ...
Emerging Therapeutic Targets Against Toxoplasma gondii: Update on DNA Repair Response Inhibitors and Genotoxic Drugs
(Frontiers Media S.A., 2020-06)
Toxoplasma gondii is the causative agent of toxoplasmosis in animals and humans. This infection is transmitted to humans through oocysts released in the feces of the felines into the environment or by ingestion of undercooked ...
Oxidative Stress and Genomic Damage Induced In Vitro in Human Peripheral Blood by Two Preventive Treatments of Iron Deficiency Anemia
(Humana Press, 2019-08)
Iron deficiency is the most prevalent nutritional deficiency and the main cause of anemia worldwide. Since children aged 6–24 months are among the most vulnerable groups at risk, daily supplementation with ferrous sulfate ...
In vitro studies of cellular response to DNA damage induced by boron neutron capture therapy
(Pergamon-Elsevier Science Ltd, 2011-12)
The aim of these studies was to evaluate the mechanisms of cellular response to DNA damage induced by BNCT. Thyroid carcinoma cells were incubated with 10BPA or 10BOPP and irradiated with thermal neutrons. The surviving ...
Liver mitochondrial DNA damage and genetic variability of Cytochrome b – a key component of the respirasome – drive the severity of fatty liver disease
(Wiley Blackwell Publishing, Inc, 2020-07-07)
Background and aims: The progression of nonalcoholic fatty liver disease (NAFLD) into severe histological forms (steatohepatitis – NASH) is paralleled by the occurrence of complex molecular processes. Mitochondrial dysfunction ...
Editorial: Plant Genome-Epigenome Integrity Under Environmental Stress
(Frontiers Media, 2020-08)
Plants, due to their sessile life style, need to cope with different environmental stresses to allow proper growth and development. DNA, in association with histones, is packaged into chromatin. Several changes in chromatin ...